Comparison of Immune Restoration in Early versus Late Alpha Interferon Therapy against Hepatitis C Virus
Comparison of Immune Restoration in Early versus Late Alpha Interferon Therapy against Hepatitis C Virus
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DOI：
10.1128/jvi.01094-10
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发表时间：
2010-10-01
影响因子：
5.4
通讯作者：
Shoukry, Naglaa H.
中科院分区：
文献类型：
--
作者：
Abdel-Hakeem, Mohamed S.;Bedard, Nathalie;Shoukry, Naglaa H.
丙型肝炎病毒的早期干扰素治疗可以挽救多功能的、病毒特异性的记忆性CD8(+)T细胞，但在晚期治疗期间是否有可能恢复免疫仍存在争议。我们比较了自发清除丙型肝炎病毒感染的患者和接受早期或晚期干扰素治疗的患者丙型肝炎病毒特异性记忆T细胞的免疫恢复。在自发解决者和急性感染后早期治疗的患者中，检测到多功能CD4(+)和CD8(+)记忆T细胞。相比之下，在慢性感染期间接受治疗的患者检测到有限的反应，并且丙型肝炎病毒特异性细胞的表型受到自体病毒序列的影响。我们的数据表明，丙型肝炎病毒特异性记忆T细胞反应的不可逆转损害与慢性丙型肝炎病毒感染有关。
Early alpha interferon (IFN-alpha) therapy against hepatitis C virus (HCV) rescues polyfunctional, virus-specific memory CD8(+) T cells, but whether immune restoration is possible during late therapy remains controversial. We compared immune restoration of HCV-specific memory T cells in patients who cleared HCV infection spontaneously and following early or late IFN therapy. Multifunctional CD4(+) and CD8(+) memory T cells were detected in spontaneous resolvers and in individuals treated early following an acute infection. In contrast, limited responses were detected in patients treated during chronic infection, and the phenotype of HCV-specific cells was influenced by autologous viral sequences. Our data suggest that irreversible damage to the HCV-specific memory T-cell response is associated with chronic HCV infection.