Immunopathology of schistosomiasis: a cautionary tale of mice and men
Immunopathology of schistosomiasis: a cautionary tale of mice and men
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DOI：
10.1016/s0167-5699(99)01551-0
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Fallon, PG
中科院分区：
文献类型：
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作者：
Fallon, PG
小鼠实验模型已被广泛用于证明1型或2型细胞因子反应的特异性优势将影响感染多种病原体的结局。在这里，以人类蠕虫感染为例，Padraic Fallon说明了从细胞因子相关的免疫病理学角度从小鼠推断到人类的问题。
Murine experimental models have been used extensively to demonstrate that the specific dominance of a type 1 or type 2 cytokine response will influence the outcome of infection with a number of pathogens. Here, using a human helminth infection as an example, Padraic Fallon illustrates the problems of extrapolating from mouse to humans with respect to cytokine-associated immunopathology.