ALPHA-SMOOTH MUSCLE ACTIN AND OTHER STROMAL MARKERS IN ENDOMETRIAL MUCOSA
ALPHA-SMOOTH MUSCLE ACTIN AND OTHER STROMAL MARKERS IN ENDOMETRIAL MUCOSA
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DOI：
10.1007/bf01608341
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发表时间：
1993-04-01
期刊：
影响因子：
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通讯作者：
GABBIANI, G
中科院分区：
文献类型：
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作者：
CZERNOBILSKY, B;REMADI, S;GABBIANI, G
研究了正常子宫内膜和病理性子宫内膜间质-上皮细胞之间的相互作用，分别表达了α-平滑肌肌动蛋白、纤维连接蛋白、层粘连蛋白和张力蛋白。α-SM肌动蛋白对分散的子宫内膜腺有完全或不完全的切割作用，主要位于子宫内膜黏膜的基底层和扩张或囊性腺体内。单个腺癌腺体周围未见α-SM肌动蛋白阳性细胞。无论腺体周围是否存在α-SM肌动蛋白，IV型胶原和层粘连蛋白都存在于所有腺体周围。纤维连接蛋白广泛存在于间质中。Tenascin被发现，尽管不是唯一的，在一个类似于α-SM肌动蛋白的腺体周围位置。我们认为，细胞角蛋白阴性的腺周细胞可能是肌成纤维细胞。由于这种现象在扩张和囊性腺体中最常见，我们认为这些腺体周围的间质细胞可能会受到机械或其他压力，导致MFS的发生，就像在其他组织重塑的情况下一样。这也可能解释了Tenascin出现在同一位置的原因。因此，我们的发现可能代表了基质细胞表型局部调控的进一步例子，可能是在微环境因素的作用下。
Stromal-epithelial interactions as expressed by alpha-smooth muscle actin (alpha-SM actin) collagen type IV, fibronectin, laminin and tenascin were studied in normal and pathological endometrial mucosa. There was complete or incomplete cuffing of scattered endometrial glands by alpha-SM actin mostly in the basal layer of endometrial mucosa and in dilated or cystic glands. Individual adenocarcinomatous glands were not encircled by alpha-SM actin-positive cells. Collagen type IV and laminin were found surrounding all glands irrespective of the presence of periglandular alpha-SM actin. Fibronectin was diffusely present in the stroma. Tenascin was identified, albeit not exclusively, in a periglandular location similar to that of alpha-SM actin. We conclude that the periglandular cells staining for alpha-SM actin, which were negative for cytokeratins, are probably myofibroblasts (MFs). Since this phenomenon was most commonly observed in dilated and cystic glands, we suggest that stromal cells immediately surrounding these glands may be subjected to mechanical or other stress resulting, as in other situations of tissue remodelling, in the development of MFs. This may also explain the appearance of tenascin in the same location. Thus, our finding may represent a further example of the local modulation of stromal cell phenotype, possibly under the action of micro-environmental factors.