Imaging metabolic heterogeneity in cancer.
Imaging metabolic heterogeneity in cancer.
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DOI：
10.1186/s12943-015-0481-3
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发表时间：
2016-01-06
期刊：
影响因子：
37.3
通讯作者：
Pratx G
中科院分区：
文献类型：
--
作者：
Sengupta D;Pratx G
随着我们对癌症代谢知识的增加，癌症代谢过程的异质性已经变得很明显。造成这种异质性的原因包括遗传多样性、多种冗余代谢途径的存在、微环境条件的改变等。因此，临床和其他领域的方法已经发展起来，以便在体内和体外体制下成像和研究肿瘤代谢。这两种方法都具有独特的优势和挑战，并可用于提供肿瘤代谢异质性的空间和时间综合图像。综合起来，这些方法可能是未来适当的癌症诊断和治疗的关键。
As our knowledge of cancer metabolism has increased, it has become apparent that cancer metabolic processes are extremely heterogeneous. The reasons behind this heterogeneity include genetic diversity, the existence of multiple and redundant metabolic pathways, altered microenvironmental conditions, and so on. As a result, methods in the clinic and beyond have been developed in order to image and study tumor metabolism in the in vivo and in vitro regimes. Both regimes provide unique advantages and challenges, and may be used to provide a picture of tumor metabolic heterogeneity that is spatially and temporally comprehensive. Taken together, these methods may hold the key to appropriate cancer diagnoses and treatments in the future.