Serum IgE levels in patients with bullous pemphigoid and its correlation to the activity of the disease and anti-basement membrane zone antibodies.
Serum IgE levels in patients with bullous pemphigoid and its correlation to the activity of the disease and anti-basement membrane zone antibodies.
复制标题
大疱性类天疱疮患者血清IgE水平及其与疾病活动性和抗基底膜区抗体的相关性。
DOI：
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发表时间：
1984
影响因子：
3.6
通讯作者：
A. Hovmark
中科院分区：
文献类型：
--
作者：
E. Åsbrink;A. Hovmark
34例大疱性类天疱疮急性加重患者中有24例血清IgE水平升高。血清IgE水平或血清抗基底膜带抗体滴度与病情加重程度无统计学意义相关。然而，抗基底膜带抗体滴度与血清IgE水平呈正相关。除2例患者外，所有患者在病情加重2-4个月后血清IgE均恢复正常或下降。在许多患者中，抗基底膜带抗体滴度也有下降的趋势，但这些滴度的变化通常不能在发现血清IgE水平改变时测定。因此，在大多数患者中，血清IgE被发现是一个比间接免疫荧光更好的实验室参数，用于跟踪疾病的活动。
The serum levels of IgE were found to be increased in 24 of 34 patients with an acute exacerbation of bullous pemphigoid. There was no statistically significant correlation between the serum IgE level or the serum anti-basement membrane zone antibody titer and the extent of the disease during an exacerbation. There was however a positive correlation between anti-basement membrane zone antibody titers and serum IgE levels. All but 2 patients showed a normalisation or decline in serum IgE 2-4 months after an exacerbation of the disease. There was also a tendency to declining antibasement membrane zone antibody titers in many patients but changes of these titers could usually not be measured as early as alterations of serum IgE levels were found. Thus in most patients serum IgE was found to be a better laboratory parameter than indirect immunofluorescence for following the activity of the disease.