Color and genomic ancestry in Brazilians
Color and genomic ancestry in Brazilians
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DOI：
10.1073/pnas.0126614100
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发表时间：
2003-01-07
影响因子：
11.1
通讯作者：
Pena, SDJ
中科院分区：
文献类型：
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作者：
Parra, FC;Amado, RC;Pena, SDJ
这项工作是为了确定巴西人的外表在多大程度上可以预测基因组非洲血统。使用一组10个人群特异性等位基因，我们为每个人分配了非洲血统指数（AAI）。该程序能够区分，没有重叠，20名男性从北方葡萄牙从20名男性从非洲西海岸的圣托姆岛。我们还测试了10名巴西美洲印第安人，观察到他们的AAI值与欧洲人相同。最后，我们研究了两个不同的巴西人口样本。第一组由来自东南部农村社区的173名个体组成，根据他们的颜色（白色、黑色或中间色）进行临床分类，并基于手臂内侧的皮肤色素沉着、头发颜色和质地以及鼻子和嘴唇的形状进行多变量评估。与非洲和欧洲样本的明确结果相反，我们的结果显示三种颜色类别之间存在较大的差异和广泛的重叠。接下来，我们对200名不相关的巴西白色男性进行了研究，他们来自该国四个主要地理区域的国际化中心。结果显示，AAI值介于欧洲人和非洲人之间，即使在巴西南部，一个主要由欧洲移民居住的地区。我们的数据表明，在巴西，在个人层面上，颜色，由物理评估确定，是一个穷人的预测基因组非洲血统，估计分子标记。
This work was undertaken to ascertain to what degree the physical appearance of a Brazilian individual was predictive of genomic African ancestry. Using a panel of 10 population-specific alleles, we assigned to each person an African ancestry index (AAI). The procedure was able to tell apart, with no overlaps, 20 males from northern Portugal from 20 males from Sao Tome Island on the west coast of Africa. We also tested 10 Brazilian Amerindians and observed that their AAI values fell in the same range as the Europeans. Finally, we studied two different Brazilian population samples. The first consisted of 173 individuals from a rural Southeastern community, clinically classified according to their Color (white, black, or intermediate) with a multivariate evaluation based on skin pigmentation in the medial part of the arm, hair color and texture, and the shape of the nose and lips. In contrast to the clear-cut results with the African and European samples, our results showed large variances and extensive overlaps among the three Color categories. We next embarked on a study of 200 unrelated Brazilian white males who originated from cosmopolitan centers of the four major geographic regions of the country. The results showed AAI values intermediate between Europeans and Africans, even in southern Brazil, a region predominantly peopled by European immigrants. Our data suggest that in Brazil, at an individual level, color, as determined by physical evaluation, is a poor predictor of genomic African ancestry, estimated by molecular markers.