Exhaled nitric oxide is reduced in infants with cystic fibrosis
Exhaled nitric oxide is reduced in infants with cystic fibrosis
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DOI：
10.1136/thorax.56.2.151
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发表时间：
2001-02-01
期刊：
影响因子：
10
通讯作者：
Everard, ML
中科院分区：
文献类型：
--
作者：
Elphick, HE;Demoncheaux, EAG;Everard, ML
背景：尽管存在气道慢性炎症，囊性纤维化（CF）患者呼出的一氧化氮水平较低。本研究的目的是确定是否呼出的一氧化氮水平降低之前的呼吸系统症状的婴儿CE方法的呼出的一氧化氮水平进行了测量，使用化学发光分析仪在5名婴儿CF和11名健康对照组，两组的平均年龄为48.6天。结果CF婴儿呼出气一氧化氮的平均水平显著低于对照组（4.9 ppb v 12.1 ppb; p=0.01）。结论这一发现可能是理解早期囊性纤维化炎症过程的关键，并可能导致新的治疗方法。（Thorax 2001;56：151-152）。
Background-Exhaled nitric oxide levels are low in patients with cystic fibrosis (CF), despite the chronic inflammation present in the airways. This study aimed to determine whether levels of exhaled nitric oxide were reduced prior to the onset of respiratory symptoms in infants with CEMethods-The levels of exhaled nitric oxide were measured using a chemiluminescence analyser in five infants with CF and 11 healthy control subjects, both groups having a mean age of 48.6 days. Results-Mean levels of exhaled nitric oxide were significantly lower in infants with CF than in the control group (4.9 ppb v 12.1 ppb; p=0.01).Conclusions-This finding may be the key to understanding the inflammatory processes in early cystic fibrosis and may lead to novel treatment approaches. (Thorax 2001;56:151-152).