Magnetic Resonance Imaging for the Detection, Localisation, and Characterisation of Prostate Cancer: Recommendations from a European Consensus Meeting
Magnetic Resonance Imaging for the Detection, Localisation, and Characterisation of Prostate Cancer: Recommendations from a European Consensus Meeting
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DOI：
10.1016/j.eururo.2010.12.009
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发表时间：
2011-04-01
期刊：
影响因子：
23.4
通讯作者：
Emberton, Mark
中科院分区：
文献类型：
--
作者：
Dickinson, Louise;Ahmed, Hashim U.;Emberton, Mark
背景：多参数磁共振成像（mpMRI）可能在血清前列腺特异性抗原水平升高的男性中检测具有临床意义的前列腺癌。技术和图像解释的变化导致其报告的性能特征不一致。目的：我们的目的是为前列腺癌检测和定位的前列腺mpMRI的实施、解释和报告的标准化方法提出建议。设计、设置和参与者：16位欧洲前列腺癌专家按照UCLA-RAND适当性方法召开了一次共识会议，并由一位独立主席促成。测量：在会议之前，小组成员对520个项目的“适当性”进行评分，面对面讨论，并重新进行评分。结果与局限性：260项成像序列参数的一致性达到67%。t2加权、动态对比增强和弥散加权MRI是纳入最低要求的关键序列。在与图像解释和报告相关的260个项目中，包括个别序列的恶性特征，其中54%达成了共识。在传达恶性肿瘤的可能性时，我们同意采用5分制，至少有16个感兴趣的前列腺区域，包括可疑病灶的图像表示。限制与共识方法有关。众所周知，强势人格会影响团队的意见，并由中立的主席来反驳。结论：关于mpMRI在前列腺癌的检测、定位和表征方面的实施、解释和报告的一些领域达成了共识。在这项技术的最佳传播之前，这些结果将需要在前瞻性试验中进行正式验证。(C) 2010年欧洲泌尿外科协会。Elsevier B.V.版权所有。
Background: Multiparametric magnetic resonance imaging (mpMRI) may have a role in detecting clinically significant prostate cancer in men with raised serum prostate-specific antigen levels. Variations in technique and the interpretation of images have contributed to inconsistency in its reported performance characteristics.Objective: Our aim was to make recommendations on a standardised method for the conduct, interpretation, and reporting of prostate mpMRI for prostate cancer detection and localisation.Design, setting, and participants: A consensus meeting of 16 European prostate cancer experts was held that followed the UCLA-RAND Appropriateness Method and facilitated by an independent chair.Measurement: Before the meeting, 520 items were scored for "appropriateness" by panel members, discussed face to face, and rescored.Results and limitations: Agreement was reached in 67% of 260 items related to imaging sequence parameters. T2-weighted, dynamic contrast-enhanced, and diffusion-weighted MRI were the key sequences incorporated into the minimum requirements. Consensus was also reached on 54% of 260 items related to image interpretation and reporting, including features of malignancy on individual sequences. A 5-point scale was agreed on for communicating the probability of malignancy, with a minimum of 16 prostatic regions of interest, to include a pictorial representation of suspicious foci. Limitations relate to consensus methodology. Dominant personalities are known to affect the opinions of the group and were countered by a neutral chairperson.Conclusions: Consensus was reached on a number of areas related to the conduct, interpretation, and reporting of mpMRI for the detection, localisation, and characterisation of prostate cancer. Before optimal dissemination of this technology, these outcomes will require formal validation in prospective trials. (C) 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.