Host and microbial factors in regulation of T cells in the intestine.
Host and microbial factors in regulation of T cells in the intestine.
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DOI：
10.3389/fimmu.2013.00141
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发表时间：
2013
影响因子：
7.3
通讯作者：
Kim CH
中科院分区：
文献类型：
--
作者：
Kim CH
肠道被分成专门的组织区域，为T细胞提供不同的微环境。肠道中T细胞反应的调节一直是该领域最近研究活动的主要焦点。肠道中的T细胞受宿主和微生物因素之间的相互作用调节。在小肠中，视黄酸（RA）是一种主要的组织因子，在免疫应答的调节中起重要作用。在大肠中，RA的影响减弱，但肠道细菌产物的影响增加。RA、肠道微生物群和炎症介质共同调节T细胞的分化、分布和/或效应子功能。这些因子对免疫应答的协调调节促进了良好平衡的免疫和免疫耐受。这一过程的失调可增加感染和炎性疾病。
The intestine is divided into specialized tissue areas that provide distinct microenvironments for T cells. Regulation of T-cell responses in the gut has been a major focus of recent research activities in the field. T cells in the intestine are regulated by the interplay between host and microbial factors. In the small intestine, retinoic acid (RA) is a major tissue factor that plays important roles in regulation of immune responses. In the large intestine, the influence of RA diminishes, but that of commensal bacterial products increases. RA, gut microbiota, and inflammatory mediators co-regulate differentiation, distribution, and/or effector functions of T cells. Coordinated regulation of immune responses by these factors promotes well-balanced immunity and immune tolerance. Dysregulation of this process can increase infection and inflammatory diseases.