Middle-range exploratory activity in adult rats suggests higher resilience to chronic social defeat
Middle-range exploratory activity in adult rats suggests higher resilience to chronic social defeat
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成年大鼠的中等探索活动表明对长期社会失败的恢复能力更高
DOI：
10.1017/neu.2015.64
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Harro J
中科院分区：
文献类型：
--
作者：
Matrov D;Kõiv K;Kanarik M;Peet K;Raudkivi K;Harro J
目的压力生活事件在人类情绪障碍的病因学中发挥着重要作用，并且经常以啮齿类动物的慢性社交失败（SD）为模型。大鼠的探索性表型是一种稳定的特征，可能与个体间对压力的反应差异有关。本研究的目的是确认啮齿动物中低水平的探索活动（LE）是被动应激应对的危险因素，并阐明中（ME）和高（HE）探索倾向在SD敏感性中的作用。方法我们检查了SD对雄性Wistar大鼠在探索盒中测量的LE、ME和HE活动水平的影响。 SD后，对大鼠进行社会偏好、高架零迷宫和旷场测试的评估。采用高效液相色谱法测定脑组织中的单胺水平。结果SD组大鼠体重增加较低，蔗糖消耗较高，应激引起的体温升高较大，额叶皮层高香草酸水平较低，杏仁核和海马去甲肾上腺素水平较高。开放场、高架零迷宫和社会偏好测试揭示了压力和表型之间的相互作用，因为只有 LE 大鼠受到 SD 的进一步抑制。 ME-大鼠在体重变化、压力引起的体温升高和蔗糖摄入方面表现出对压力的反应性最小。结论低和高的新奇相关活动，尤其是前者，都与对社会压力的敏感性升高有关。这项研究表明，行为维度的两个尾巴都会产生与压力相关的脆弱性。
ObjectiveStressful life events play an important role in the aetiology of human mood disorders and are frequently modelled by chronic social defeat (SD) in rodents. Exploratory phenotype in rats is a stable trait that is likely related to inter-individual differences in reactivity to stress. The aim of the study was to confirm that low levels of exploratory activity (LE) are, in rodents, a risk factor for passive stress coping, and to clarify the role of medium (ME) and high (HE) exploratory disposition in the sensitivity to SD.MethodsWe examined the effect of SD on male Wistar rats with LE, ME, and HE activity levels as measured in the exploration box. After SD, the rats were evaluated in social preference, elevated zero maze, and open-field tests. Brain tissue levels of monoamines were measured by high-performance liquid chromatography.ResultsRats submitted to SD exhibited lower weight gain, higher sucrose consumption, showed larger stress-induced hyperthermia, lower levels of homovanillic acid in the frontal cortex, and higher levels of noradrenaline in the amygdala and hippocampus. Open-field, elevated zero maze, and social preference tests revealed the interaction between stress and phenotype, as only LE-rats were further inhibited by SD. ME-rats exhibited the least reactivity to stress in terms of changes in body weight, stress-induced hyperthermia, and sucrose intake.ConclusionBoth low and high novelty-related activity, especially the former, are associated with elevated sensitivity to social stress. This study shows that both tails of a behavioural dimension can produce stress-related vulnerability.