Branched-chain amino acids may improve recovery from a vegetative or minimally conscious state in patients with traumatic brain injury: A pilot study
Branched-chain amino acids may improve recovery from a vegetative or minimally conscious state in patients with traumatic brain injury: A pilot study
复制标题
DOI：
10.1016/j.apmr.2008.02.023
复制
发表时间：
2008-09-01
影响因子：
4.3
通讯作者：
Verri, Manuela
中科院分区：
文献类型：
--
作者：
Aquilani, Roberto;Boselli, Mirella;Verri, Manuela
目的：为了研究补充支链氨基酸（BCAA）是否可以改善创伤后植物人或最低意识状态患者的恢复，设计：患者被随机分配到15天的静脉内BCAA补充（n=22，研究对象：创伤后植物人或最小意识状态患者（男29例，女12例，平均年龄49.5 ± 21岁）。干预：补充支链氨基酸。主要结果测量：残疾评定量表（DRS）作为log（10）DRS。结果：在进入康复科15天后，只有接受BCAA的患者的log（10）DRS评分显著改善（log（10）DRS评分，1.365 +/- 0.08至1.294 +/- 0.05-，P
Objective: To investigate whether Supplementation With branched-chain amino acids (BCAAs) may improve recovery of patients with a posttramatic vegetative or minimally conscious state.Design: Patients were randomly assigned to 15 days of intravenous BCAA Supplementation (n=22., 19.6g/d) or all isonitrogenous placebo (n = 19).Setting: Tertiary care rehabilitation setting.Participants: Patients (N=41: 29 men, 12 women, mean age,49.5 +/- 21y) with a posttraumatic vegetative or minimally conscious state. 47 24 days after the index traumatic event.Intervention: Supplementation with BCAAs.Main Outcome Measure: Disability Rating Scale (DRS) as log(10)DRS.Results: Fifteen days after admission to the rehabilitation department, the log(10)DRS score improved significantly only in patients who had received BCAAs (log(10)DRS score, 1.365 +/- 0.08 to 1.294 +/- 0.05-, P