Insulin resistance and outcome in bipolar disorder
Insulin resistance and outcome in bipolar disorder
复制标题
DOI：
10.1192/bjp.bp.114.152850
复制
发表时间：
2015-01-01
影响因子：
10.5
通讯作者：
Alda, Martin
中科院分区：
文献类型：
--
作者：
Calkin, Cynthia V.;Ruzickova, Martina;Alda, Martin
BackgroundLittle是所知的胰岛素抵抗对双相障碍的影响。AimsTo研究胰岛素抵抗，2型糖尿病和临床病程和治疗结果之间的关系在bipolardisorder.Methods我们测量了空腹血糖和胰岛素在121名成人双相障碍。我们诊断为2型糖尿病，并确定胰岛素抵抗。采用美国国家精神卫生研究所生命图记录双相情感障碍的病程，并采用Alda量表建立对预防性锂治疗的反应。结果与正常人相比，双相情感障碍和2型糖尿病或胰岛素抵抗患者双相情感障碍慢性病程的几率高3倍（50%和48.7%分别对27.3%，比值比（OR）=3.07，P=0.007），快速循环的几率高3倍（分别为38.5%和39.5% v. 1.8.2%，OR=3.13，P=0.012），更可能对锂治疗无效（分别为36.8%和36.7% v. 3.2%，OR=8.40，P
BackgroundLittle is known about the impact of insulin resistance on bipolar disorder.AimsTo examine the relationships between insulin resistance, type 2 diabetes and clinical course and treatment outcomes in bipolar disorder.MethodWe measured fasting glucose and insulin in 121 adults with bipolar disorder. We diagnosed type 2 diabetes and determined insulin resistance. The National Institute of Mental Health Life Chart was used to record the course of bipolar disorder and the Alda scale to establish response to prophylactic lithium treatment.ResultsPatients with bipolar disorder and type 2 diabetes or insulin resistance had three times higher odds of a chronic course of bipolar disorder compared with euglycaemic patients (50% and 48.7% respectively v. 27.3%, odds ratio (OR)=3.07, P=0.007), three times higher odds of rapid cycling (38.5% and 39.5% respectively v. 1.8.2%, OR=3.13, P=0.012) and were more likely to be refractory to lithium treatment (36.8% and 36.7% respectively v. 3.2%, OR=8.40, P