Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol
Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol
复制标题
DOI：
10.1007/s00259-006-0318-9
复制
发表时间：
2007-07-01
影响因子：
9.1
通讯作者：
Jacobsson, Hans
中科院分区：
文献类型：
--
作者：
Soderlund, Veli;Larsson, Stig A.;Jacobsson, Hans
目的在FDG-PET检查中，有时可以看到棕色脂肪组织(冬眠脂肪)的摄取。尽管有特征性的外观，但这可能隐藏了临床上的相关吸收。刺激交感神经系统会增加棕色脂肪对葡萄糖的摄取。我们现在重新检查棕色脂肪活动可能掩盖肿瘤摄取的患者，在用普萘洛尔(一种非选择性β-受体阻滞剂)预治疗后，以减少摄取。方法对11例棕色脂肪摄取较强的患者进行研究。两次检查的间隔时间平均为5天(2-8天)。复查时，于FDG给药前2小时口服心得安80 mg。结果所有患者在复查时(P<；0.001)，无论是目测还是比较SUV，均显示棕色脂肪活性完全或几乎消失。在7名患者中，已知的或高度怀疑的恶性肿瘤也有摄取，但在两次检查之间保持不变。除心肌摄取无明显下降外，复查时各受检器官未见再分布。结论单剂量心得安预处理可阻断棕色脂肪组织对FDG的摄取，从而提高复查的特异性。肿瘤的摄取似乎没有受到损害。
Purpose Uptake in brown adipose tissue (hibernating fat) is sometimes seen at FDG-PET examinations. Despite a characteristic appearance, this may hide clinically relevant uptake. Stimulation of the sympathetic nervous system increases glucose uptake of brown fat. We now re-examine patients with brown fat activity that could disguise tumour uptake after pre-treatment with propranolol (a non-selective beta-blocker) in order to reduce the uptake. Our first examinations of this kind are reported.Methods Eleven patients with strong brown fat uptake were studied. There was a mean of 5 days (range 2-8) between the examinations. At the second examination, 80 mg of propranolol was given orally 2 h before FDG administration. In addition to visual evaluation of the brown fat uptake, SUV assessments of the uptake in brown fat, lung, heart, liver, spleen and bone marrow were made.Results All patients showed complete or almost complete disappearance of the brown fat activity at the second examination (p < 0.001) both upon visual evaluation and when comparing SUVs. In seven patients there was also uptake in a known or strongly suspected malignancy, which remained unchanged between the examinations. Beyond an insignificant decrease in the myocardial uptake, there was no redistribution to the various examined organs at the second examination.Conclusion Pre-treatment with a single dose of propranolol blocks the FDG uptake in brown adipose tissue, thereby increasing the specificity of the examination. The tumour uptake seems not to be impaired.