Breast cancer, stem cells and sex hormones: part 1. The impact of fetal life and infancy.
Breast cancer, stem cells and sex hormones: part 1. The impact of fetal life and infancy.
复制标题
乳腺癌、干细胞和性激素：第 1 部分。对胎儿生命和婴儿期的影响。
DOI：
10.1016/j.maturitas.2010.05.005
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发表时间：
2010
期刊：
影响因子：
4.9
通讯作者：
J. Eden
中科院分区：
文献类型：
--
作者：
J. Eden
像其他器官一样，乳房含有罕见的体干细胞（SC），它们寿命长，分裂缓慢。在成年乳腺中，它们在位于沿着乳腺导管的称为SC小生境的区域中受到密切调节。乳腺干细胞可以产生后代，成为导管，肺泡或肌上皮细胞。在胎儿期，SC形成原始乳腺导管，直到胎龄30周，这一过程似乎在很大程度上不依赖于雌激素。乳腺癌的早期风险因素包括出生体重、婴儿期快速生长和饮食。这些风险因素的影响可能通过SC编号介导。这些体细胞乳腺SC持续到成年，因此它们暴露于致癌影响的时间比短寿命的分化的乳腺导管和肺泡细胞长得多。因此，乳腺SC可能是致癌作用的主要靶点，因此SC数量可能是日后患乳腺癌风险的重要决定因素。
Like other organs, the breast contains rare somatic stem cells (SCs) that are long-lived and slowly dividing. In the adult breast, they are closely regulated in areas located along the breast ducts called SC niches. Breast SCs can produce offspring that become ductal, alveoli or myoepithelial cells. In fetal life, SCs form the primitive breast ducts and up to 30 weeks of gestational age, this process appears to be largely independent of estrogen. Early life risk factors for breast cancer include birth weight, rapid growth during infancy and diet. The impact of these risk factors may be mediated through SC number. These somatic breast SCs persist into adult life and so they are exposed to oncogenic influences for much longer than the short-lived differentiated breast ductal and alveolar cells. As such, it is likely that the breast SC is a prominent target for carcinogenesis and so SC number may be an important determinant of breast cancer risk later in life.