CHLOROQUINE - MODE OF ACTION
CHLOROQUINE - MODE OF ACTION
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DOI：
10.1126/science.151.3708.347
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发表时间：
1966-01-01
期刊：
影响因子：
56.9
通讯作者：
HAHN, FE
中科院分区：
文献类型：
--
作者：
CIAK, J;HAHN, FE
药物氯喹对巨大芽孢杆菌有杀菌作用;它抑制DNA和RNA的生物合成，并使核糖体迅速降解和核糖体RNA异化。还观察到蛋白质合成的抑制，这显然是次要效应。DNA复制的抑制被认为是氯喹抗菌作用的一般机制。
The drug chloroquine is bactericidal forBacillus megaterium; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.