Feasibility of Confocal Laser Microscopy in CT-Guided Needle Biopsy of Pulmonary and Mediastinal Tumors: A Proof-of-Concept Pilot Study
Feasibility of Confocal Laser Microscopy in CT-Guided Needle Biopsy of Pulmonary and Mediastinal Tumors: A Proof-of-Concept Pilot Study
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DOI：
10.1016/j.jvir.2015.10.008
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发表时间：
2016-02-01
影响因子：
2.9
通讯作者：
Lieberman, Sivan
中科院分区：
文献类型：
--
作者：
Shulimzon, Tiberiu R.;Lieberman, Sivan
本文介绍了利用激光共聚焦显微镜(CLM)结合CT引导下的经胸穿针活检(TTNB)诊断异质性大、纵隔和肺肿瘤。5名被诊断为纵隔肿块的患者和5名被诊断为肺部肿块的患者接受了这项手术。CT导引下TTNB术前行CLM检查。使用荧光素可以识别这两个部位的血管。纵隔肿块内可见恶性细胞。并发症包括1例气胸。在大型肿瘤中，CLM允许在活检前将血管组织与坏死区和纤维区区分开来。
This report describes the use of confocal laser microscopy (CLM) with CT-guided transthoracic needle biopsy (TTNB) for the diagnosis of heterogeneous large, mediastinal and lung tumors. The procedure was performed in five patients diagnosed with a mediastinal mass and five patients diagnosed with a lung mass. CLM was used before CT-guided TTNB. Fluorescein administration allowed for the identification of blood vessels in both locations. Malignant cells were identified in mediastinal masses. Complications included one case of pneumothorax. In large tumors, CLM allows vascularized tissue to be differentiated from necrotic and fibrotic areas before biopsy.