Study Protocol: Multimodal Longitudinal Assessment of Infant Brain Organization and Recovery in Perinatal Brain Injury.
Study Protocol: Multimodal Longitudinal Assessment of Infant Brain Organization and Recovery in Perinatal Brain Injury.
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DOI：
10.1097/pep.0000000000000886
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发表时间：
2022-04-01
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围产期脑损伤是脑瘫的主要原因，脑瘫是一种导致终身运动障碍的疾病。婴儿期是运动系统发育的重要时期，包括皮质脊髓束（CST）的发育，皮质运动控制的主要途径。围产期中风恢复，CST组织和由此产生的婴儿运动结果之间的相互作用还没有很好的理解。在这里，我们提出了一个多模式的纵向评估围产期脑损伤后的大脑发育和运动功能的协议，使用经颅磁刺激和磁共振成像的非侵入性测量CST功能和结构的完整性在多个时间点在婴儿3至24个月的年龄。我们将进一步评估皮质兴奋性、完整性和运动功能之间的关联。该方案将确定运动结果和神经可塑性的生物指标，并随后为患有围产期中风，脑出血和相关诊断的婴儿提供早期检测，诊断和干预策略。
Perinatal brain injury is a primary cause of cerebral palsy, a condition resulting in life-long motor impairment. Infancy is an important period of motor system development, including development of the corticospinal tract (CST), the primary pathway for cortical movement control. The interaction between perinatal stroke recovery, CST organization, and resultant motor outcome in infants is not well understood. Here, we present a protocol for multimodal longitudinal assessment of brain development and motor function following perinatal brain injury using transcranial magnetic stimulation and magnetic resonance imaging to non-invasively measure CST functional and structural integrity across multiple timepoints in infants 3 to 24 months of age. We will further assess the association between cortical excitability, integrity, and motor function. This protocol will identify bioindicators of motor outcome and neuroplasticity, and subsequently inform early detection, diagnosis, and intervention strategies for infants with perinatal stroke, brain bleeds and related diagnoses.