Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus
Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus
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DOI：
10.1016/j.neuron.2005.04.011
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发表时间：
2005-05-19
期刊：
影响因子：
16.2
通讯作者：
Anderson, DJ
中科院分区：
文献类型：
--
作者：
Choi, GB;Dong, HW;Anderson, DJ
在哺乳动物中，先天生殖和防御行为是由杏仁核与下丘脑之间的解剖学隔离联系介导的。这种解剖隔离提出了一个问题，即面对这种互斥行为的刺激矛盾时，大脑如何整合这些电路中的活动。使用遗传编码和常规的轴突示踪剂，我们发现转录因子LHX6描述了该途径的生殖分支。其他LHX蛋白在杏仁核核中标记了与防御有关的神经元。我们已经从后内侧杏仁核中追踪了平行的投影，分别通过生殖或防御性嗅觉刺激激活到腹膜下丘脑的收敛点。这些收敛投影的相反神经递质表型提出了一种通过威胁刺激来抑制生殖行为的“栅极控制”机制。因此，我们的数据确定了一种潜在的神经底物，以整合冲突行为提示的影响以及可能有助于该基材发展的转录因子家族的影响。
In mammals, innate reproductive and defensive behaviors are mediated by anatomically segregated connections between the amygdala and hypothalamus. This anatomic segregation poses the problem of how the brain integrates activity in these circuits when faced with conflicting stimuli eliciting such mutually exclusive behaviors. Using genetically encoded and conventional axonal tracers, we have found that the transcription factor Lhx6 delineates the reproductive branch of this pathway. Other Lhx proteins mark neurons in amygdalar nuclei implicated in defense. We have traced parallel projections from the posterior medial amygdala, activated by reproductive or defensive olfactory stimuli, respectively, to a point of convergence in the ventromedial hypothalamus. The opposite neurotransmitter phenotypes of these convergent projections suggest a "gate control" mechanism for the inhibition of reproductive behaviors by threatening stimuli. Our data therefore identify a potential neural substrate for integrating the influences of conflicting behavioral cues and a transcription factor family that may contribute to the development of this substrate.