Role of microRNAs in haemopoiesis, heart hypertrophy and cancer
Role of microRNAs in haemopoiesis, heart hypertrophy and cancer
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DOI：
10.1042/bst0361206
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发表时间：
2008-12-01
影响因子：
3.9
通讯作者：
Peschle, Cesare
中科院分区：
文献类型：
--
作者：
Fontana, Laura;Sorrentino, Antonio;Peschle, Cesare
MiRNAs(MicroRNAs)是控制所有真核生物基因表达的重要调控分子。MiRNAs在细胞的增殖、分化、形态发生和凋亡等基本活动中发挥着重要作用。在造血方面，已经确定了几种基于miRNA的途径。重要的是，miRNA突变或错误表达与多种人类疾病相关。在癌症中，解除调控的miRNAs可以作为肿瘤抑制因子或癌基因发挥作用。本文综述了近年来关于miRNAs在血液学、心脏病学和肿瘤学三个不同研究领域中的作用的文献，特别是我们小组所取得的结果。
miRNAs (microRNAs) are important regulatory molecules that control gene expression in all eukaryotes. miRNAs play an essential role in basic cellular activities such as proliferation, differentiation, morphogenesis and apoptosis. in haemopoiesis, several miRNA-based pathways have been identified. Importantly, miRNA mutations or mis-expression correlate with various human diseases. in cancer, deregulated miRNAs can function as tumour suppressors or oncogenes. The present review focuses on the recent literature concerning the role of miRNAs in three different research areas: haematology, cardiology and oncology, with particular focus on the results obtained by our group.