Functional neuroanatomy of human vocalization:: An H215OPET study
Functional neuroanatomy of human vocalization:: An H215OPET study
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DOI：
10.1093/cercor/bhi061
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发表时间：
2005-12-01
期刊：
影响因子：
3.7
通讯作者：
Braun, AR
中科院分区：
文献类型：
--
作者：
Schulz, GM;Varga, M;Braun, AR
低等动物的发声与一个以中脑导水管周围灰质（PAG）为中心的内脏呼叫系统有关，PAG本身受旁正中皮质结构的调节。为了确定这一遗传上较老的系统在人类发声中所起的作用，我们使用正电子发射断层扫描对比了有声和无声语音，然后评估了显着区分这些条件的区域的功能连接。发声与增加和高度相关的活动中线结构PAG和旁正中皮质，描述在较低的哺乳动物物种。同时激活和连接的新皮层和皮层下运动区-内侧和外侧的运动前结构和基底神经节丘脑皮层电路的元素-表明一种机制，该系统可能已经在人类自愿控制的程度越来越高。此外，颞叶和小脑的区域在有声而非无声讲话时被选择性激活。这些区域的功能耦合到内脏和新皮层运动区在生产的有声语音，这表明他们可能发挥核心作用，在自我监测和反馈调节人类发声。
Vocalization in lower animals is associated with a well-described visceromotor call system centered on the mesencephalic periacqueductal grey matter (PAG), which is itself regulated by paramedian cortical structures. To determine the role this phylogenetically older system plays in human phonation, we contrasted voiced and unvoiced speech using positron emission tomography and then evaluated functional connectivity of regions that significantly differentiated these conditions. Vocalization was associated with increased and highly correlated activity within the midline structures-PAG and paramedian cortices-described in lower mammalian species. Concurrent activation and connectivity of neocortical and subcortical motor regions - medial and lateral premotor structures and elements of basal ganglia thalamocortical circuitry-suggest a mechanism by which this system may have come under an increasing degree of voluntary control in humans. Additionally, areas in the temporal lobe and cerebellum were selectively activated during voiced but not unvoiced speech. These regions are functionally coupled to both visceromotor and neocortical motor areas during production of voiced speech, suggesting they may play a central role in self-monitoring and feedback regulation of human phonation.