Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension.
Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension.
复制标题
肾素-血管紧张素-醛固酮系统在血压调节之外的作用：参与动脉高血压终末器官损害的分子和细胞机制。
DOI：
10.3390/ijms17070797
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发表时间：
2016-06-23
影响因子：
5.6
通讯作者：
Kalergis AM
中科院分区：
文献类型：
--
作者：
Muñoz-Durango N;Fuentes CA;Castillo AE;González-Gómez LM;Vecchiola A;Fardella CE;Kalergis AM
动脉高血压是世界范围内的常见疾病，也是多种复杂疾病的重要预测指标。动脉高血压可由多种因素引发，包括生理、遗传和生活方式原因。具体来说，肾素-血管紧张素-醛固酮系统的分子不仅在血压控制中发挥重要作用，而且还与动脉高血压的发生有关，因此需要进行药物干预。慢性高压会对血管系统、心脏和肾脏造成机械损伤，这是这种情况下受影响的主要器官。除机械应力外，高血压诱导的氧化应激、慢性炎症和修复机制的激活可导致终末器官损伤，主要是由纤维化引起的。临床试验表明，与安慰剂患者相比，肾素-血管紧张素-醛固酮系统干预高血压患者可降低发病率/死亡率和炎症标志物水平，证明该系统控制的不仅仅是血压。这篇综述强调了肾素-血管紧张素-醛固酮系统（RAAS）失衡对高血压以外的健康问题的有害影响，如纤维化终末器官损伤。
Arterial hypertension is a common condition worldwide and an important predictor of several complicated diseases. Arterial hypertension can be triggered by many factors, including physiological, genetic, and lifestyle causes. Specifically, molecules of the renin-angiotensin-aldosterone system not only play important roles in the control of blood pressure, but they are also associated with the genesis of arterial hypertension, thus constituting a need for pharmacological interventions. Chronic high pressure generates mechanical damage along the vascular system, heart, and kidneys, which are the principal organs affected in this condition. In addition to mechanical stress, hypertension-induced oxidative stress, chronic inflammation, and the activation of reparative mechanisms lead to end-organ damage, mainly due to fibrosis. Clinical trials have demonstrated that renin-angiotensin-aldosterone system intervention in hypertensive patients lowers morbidity/mortality and inflammatory marker levels as compared to placebo patients, evidencing that this system controls more than blood pressure. This review emphasizes the detrimental effects that a renin-angiotensin-aldosterone system (RAAS) imbalance has on health considerations above and beyond high blood pressure, such as fibrotic end-organ damage.