Molecular mechanisms orchestrating the stem cell response to translational scaffolds.
Molecular mechanisms orchestrating the stem cell response to translational scaffolds.
复制标题
协调干细胞对翻译支架反应的分子机制。
DOI：
10.1109/embc.2015.7318716
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Brown,JustinL
中科院分区：
文献类型：
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作者：
Ozdemir,Tugba;Higgins,AndrewM;Brown,JustinL
2013 年《科学展望》题为“解构维度”，指出了纤维形态对细胞表型的重要性，最后指出“确定细胞评估其环境性质的机制将促进基础细胞生物学的发展，并促进用于特定组织工程应用的合成基质的开发。”纳米纤维彻底改变了基于支架的肌肉骨骼组织方法；在促进间充质干细胞 (MSC) 向多个肌肉骨骼谱系分化方面表现出令人惊讶的功效。了解所涉及的基本机制将使基于纳米纤维的支架的未来设计能够特异性地针对谱系。本文重点介绍三种几何传感器：粘着斑、膜相关囊泡稳定和运输蛋白以及粘附连接如何；潜在地调节 MSC 谱系承诺以响应生物指导纳米纤维。
A 2013 Perspective in Science titled “Deconstructing Dimensionality” noted the importance of fiber morphology on cell phenotype, concluding with the statement “Identifying the mechanisms by which cells assess the nature of their environment will advance basic cell biology and facilitate the development of synthetic matrices for specific tissue engineering applications.” Nanofibers have revolutionized scaffold-based approaches for musculoskeletal tissues; demonstrating surprising efficacy over promoting mesenchymal stem cell, MSC, differentiation down multiple musculoskeletal lineages. Understanding the fundamental mechanisms involved will allow the future design of nanofiber-based scaffolds to target a lineage with specificity. This article focuses on how three geometry sensors: focal adhesions, membrane associated vesicle stabilizing and trafficking proteins, and adherens junctions; potentially regulate MSC lineage commitment in response to bio-instructive nanofibers.