Biology of Reproduction Highlights
Biology of Reproduction Highlights
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生殖生物学亮点
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Patricia L. Magyar
中科院分区：
文献类型：
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作者：
J. M. Wallace;Masatoshi Matsuzaki;J. Milne;M. Krisfalusi;Kiyoshi Miki;Patricia L. Magyar
少女怀孕和产妇营养过剩。在这期杂志第231页的一篇论文中，Wallace及其同事提供了一项关于营养过剩的青少年绵羊的研究的重要新结果，其中母体组织合成已被证明优先进行，并导致胎盘生长减少，因此，羔羊出生体重显着下降。作者提供了一项研究的结果，以确定生长激素是否可以通过增加胎盘大小或改变母体代谢来影响胎儿生长和身体组成。外源性生长激素对母体内分泌、代谢和身体组成的影响;然而，生长激素也增加胎儿生长和胎儿肥胖，而不影响胎盘大小。结果提供的证据表明，在妊娠后期用GH治疗母羊可以部分缓解营养过剩的经产母羊的宫内生长迟缓，而不会影响胎盘生长减少，这是人类青春期妊娠绵羊模型的特征。
Adolescent pregnancy and maternal overnourishment. In a paper on p. 231 of this issue, Wallace and colleagues provide important new results from a study of overnourished adolescent sheep in which maternal tissue synthesis has been shown to take priority and result in reduced placental growth and, consequently, a significant decrease in birth weight of the lamb. The authors provide results of a study to determine whether GH can influence fetal growth and body composition by increasing placental size or by altering maternal metabolism. The effects of exogenous GH were on maternal endocrinology, metabolism, and body composition; however, GH also increased fetal growth and fetal adiposity without affecting placental size. The results provide evidence that treatment of ewes with GH during late gestation can partially alleviate intrauterine growth retardation in overnourished primiparous ewes without affecting reduced placental growth that is characteristic of this sheep model for adolescent pregnancy in humans.