Voxelwise meta-analysis of gray matter reduction in major depressive disorder
Voxelwise meta-analysis of gray matter reduction in major depressive disorder
复制标题
重度抑郁症灰质减少的体素荟萃分析
DOI：
10.1016/j.pnpbp.2011.09.014
复制
发表时间：
2012-01-10
影响因子：
5.6
通讯作者：
Gong, Qi-Yong
中科院分区：
文献类型：
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作者：
Du, Ming-Ying;Wu, Qi-Zhu;Gong, Qi-Yong
背景资料：基于体素的形态测量学（VBM）已被广泛用于重度抑郁症（MDD）的研究，并提供了患者相对于对照组的灰质异常的累积证据。因此，我们进行了一项荟萃分析，整合报告的研究，以确定一致的灰质改变在MDD.Methods：进行了系统的搜索，以确定VBM的研究，对比MDD患者对对照组。使用激活似然估计（ALE）方法与基于秩的基因组扫描荟萃分析（GSMA）杂交，以定量估计区域灰质减少MDD.Results：共20个VBM研究比较了543例重性抑郁症患者与750名健康对照组的坐标跨研究的灰质变化进行荟萃分析。一致的灰质减少在所有MDD患者相对于健康对照组被确定在双侧前扣带皮层（ACC），右中，额下回，右海马和左thalamus.Conclusions：所有主要VBM研究的荟萃分析表明，显着的灰质减少MDD是本地化的分布式神经网络，其中包括额叶，边缘系统和丘脑区域。未来的研究将受益于使用纵向方法来检查该网络中的解剖和功能异常及其与临床特征的关系，特别是在首次发作和药物初治的MDD患者中。(C)2011 Elsevier Inc. All rights reserved.
Background: Voxel-based morphometry (VBM) has been widely used in studies of major depressive disorder (MDD) and has provided cumulative evidence of gray matter abnormalities in patients relative to controls. Thus we performed a meta-analysis to integrate the reported studies to determine the consistent gray matter alterations in MDD.Methods: A systematic search was conducted to identify VBM studies which contrasted MDD patients against a comparison group. The coordinates of gray matter change across studies were meta-analyzed using the activation likelihood estimation (ALE) method hybridized with the rank-based Genome Scan Meta-Analysis (GSMA) to quantitatively estimate regional gray matter reductions in MDD.Results: A total of 20 VBM studies comparing 543 major depressive patients with 750 healthy control subjects were included. Consistent gray matter reductions in all MDD patients relative to healthy controls were identified in the bilateral anterior cingulate cortex (ACC), right middle and inferior frontal gyrus, right hippocampus and left thalamus.Conclusions: Meta-analysis of all primary VBM studies indicates that significant gray matter reductions in MDD are localized in a distributed neural network which includes frontal, limbic and thalamic regions. Future studies will benefit from the use of a longitudinal approach to examine anatomical and functional abnormalities within this network and their relationship to clinical profile, particularly in first-episode and drug-naive MDD patients. (C) 2011 Elsevier Inc. All rights reserved.