Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning
Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning
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DOI：
10.1006/nimg.2000.0721
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发表时间：
2001-06-01
期刊：
影响因子：
5.7
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Morris, JS;Buchel, C;Dolan, RJ
我们使用事件相关的功能磁共振成像来测量志愿者受试者在获得视觉条件刺激（CS+）（愤怒的脸）和听觉非条件刺激（UCS）（厌恶，大声的噪音）之间的隐式关联期间的神经活动。三个不同的功能区域被确定在左杏仁核：一个UCS（噪音）相关的横向区域，CS+相关的腹侧区域，和背侧区域，CS+相关的反应在整个学习过程中逐渐变化。在纹外和听觉皮层中也诱发了对视觉CS+的不同神经反应，我们的研究结果表明，学习不同感觉方式的生物学显著刺激之间的关联涉及分离的杏仁核子区域和单峰感觉皮层中神经活动的平行变化，（C）2001学术出版社。
We used event-related fMRI to measure neural activity in volunteer subjects during acquisition of an implicit association between a visual conditioned stimulus (CS+) (angry face) and an auditory unconditioned stimulus (UCS) (aversive, loud noise). Three distinct functional regions were identified within left amygdala: a UCS (noise)-related lateral region, a CS+-related ventral region, and a dorsal region where CS+-related responses changed progressively across the learning session. Differential neural responses to the visual CS+ were also evoked in extrastriate and auditory cortices, Our results indicate that learning an association between biologically salient stimuli of different sensory modalities involves parallel changes of neural activity in segregated amygdala subregions and unimodal sensory cortices, (C) 2001 Academic Press.