Human Brown Adipose Tissue: What We Have Learned So Far
Human Brown Adipose Tissue: What We Have Learned So Far
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DOI：
10.2337/db15-0146
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发表时间：
2015-07-01
期刊：
影响因子：
7.7
通讯作者：
Enerback, Sven
中科院分区：
文献类型：
--
作者：
Betz, Matthias J.;Enerback, Sven
棕色脂肪组织（BAT）是一种独特的组织，当被交感神经系统激活时，能够将化学能直接转化为热量。虽然最初认为仅与人类新生儿和婴儿有关，但近年来的研究提供了明确的证据，证明BAT在人类成年人中具有活性。此外，已经清楚的是，BAT在啮齿动物和人类的胰岛素敏感性中起着重要作用。这为治疗肥胖和糖尿病的新疗法开辟了可能性。这篇综述总结了目前的研究状况，特别关注BAT和成人胰岛素抵抗的最新进展。此外，我们还对BAT在治疗肥胖症和糖尿病方面未来可能的治疗用途进行了展望。
Brown adipose tissue (BAT) is a unique tissue that is able to convert chemical energy directly into heat when activated by the sympathetic nervous system. While initially believed to be of relevance only in human newborns and infants, research during recent years provided unequivocal evidence of active BAT in human adults. Moreover, it has become clear that BAT plays an important role in insulin sensitivity in rodents and humans. This has opened the possibility for exciting new therapies for obesity and diabetes. This review summarizes the current state of research with a special focus on recent advances regarding BAT and insulin resistance in human adults. Additionally, we provide an outlook on possible future therapeutic uses of BAT in the treatment of obesity and diabetes.