An integrated model for the nucleo-cytoplasmic transport of cytoplasmic poly(A)-binding proteins.
An integrated model for the nucleo-cytoplasmic transport of cytoplasmic poly(A)-binding proteins.
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DOI：
10.4161/cib.19347
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发表时间：
2012-05-01
影响因子：
--
通讯作者：
Gray, Nicola K
中科院分区：
文献类型：
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作者：
Burgess, Hannah M;Gray, Nicola K
细胞质多聚（A）结合蛋白（PABPs）调节mRNA的稳定性和翻译。尽管PABP蛋白主要定位于细胞质，但也在细胞核中循环。近期的研究表明，细胞受到诸如紫外线（UV）辐射以及几种病毒感染等应激时，其稳态定位会发生改变，导致PABPs在细胞核内积累。在此，我们进一步提供证据表明它们与mRNA及翻译复合物的相互作用以及从其中的释放对于决定其亚细胞分布非常重要，并提出了一个关于PABPs受调控的核质运输的综合模型。
Cytoplasmic poly(A)-binding proteins (PABPs) regulate mRNA stability and translation. Although predominantly localized in the cytoplasm, PABP proteins also cycle through the nucleus. Recent work has established that their steady-state localization can be altered by cellular stresses such as ultraviolet (UV) radiation, and infection by several viruses, resulting in nuclear accumulation of PABPs. Here, we present further evidence that their interaction with and release from mRNA and translation complexes are important in determining their sub-cellular distribution and propose an integrated model for regulated nucleo-cytoplasmic transport of PABPs.