Increased serum retinol-binding protein-4 levels in pregnant women with and without gestational diabetes mellitus
Increased serum retinol-binding protein-4 levels in pregnant women with and without gestational diabetes mellitus
复制标题
患有或不患有妊娠期糖尿病的孕妇血清视黄醇结合蛋白 4 水平升高
DOI：
10.1016/j.diabet.2010.06.006
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发表时间：
2010-12-01
影响因子：
7.2
通讯作者：
Wang, W. -Q.
中科院分区：
文献类型：
--
作者：
Su, Y. -X.;Hong, J.;Wang, W. -Q.
目标。-视黄醇结合蛋白4(RBP4)被认为与人类的胰岛素抵抗有关，而怀孕通常以进行性胰岛素抵抗为特征。妊娠期糖尿病(GDM)发生在胰岛β细胞功能不能补偿胰岛素抵抗时。本研究旨在确定妊娠期血清RBP4水平是否升高，并探讨妊娠期RBP4水平与胰岛素抵抗的关系。-在孕26周的中位数，测定121名孕妇的血清RBP4，包括63名妊娠期糖尿病(GDM组)和58名正常糖耐量孕妇(P-NGT组)，以及65名未怀孕的正常糖耐量妇女(NP-NGT组)。采用多元逐步回归分析探讨RBP4的独立影响因素。-在调整了年龄、体重指数和血压后，P-NGT和GDM组的血清RBP4水平显著高于NP-NOT组(分别为34.5±9.80 mg/L和41.64+/-12.21 mg/L vs30.64+/-9.46 mg/L；P<；0.05)。此外，GDM组的RBP4水平明显高于P-NGT组。Spearman相关分析显示，孕期血清RBP4水平与甘油三酯(TG)、空腹血糖、餐后2 h血糖、HOMA-IR呈正相关。其中，甘油三酯和HOMA-IR是影响血清RBP4的独立因素(r(2)=0.312)。-妊娠期血清RBP4水平显著升高，与年龄和BMI无关，妊娠期糖尿病孕妇的血清RBP4水平也显著高于糖耐量正常的孕妇。此外，血清RBP4水平似乎是妊娠期胰岛素抵抗和脂代谢紊乱的一个有价值的标志物。(C)2010年，由爱思唯尔·马森公司出版。
Objective. - Retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans, while pregnancy is normally characterized by progressive insulin resistance. Gestational diabetes (GDM) occurs when pancreatic beta-cell function is unable to compensate for insulin resistance. This study aimed to determine whether or not serum RBP4 levels are elevated in pregnancy, and to explore the relationship between RBP4 levels and insulin resistance during pregnancy.Methods. - Serum RBP4 was measured at median gestational week 26 in 121 pregnant women, including 63 with GDM (GDM group) and 58 normal, glucose-tolerant pregnant women (P-NGT group), as well as 65 non-pregnant normal, glucose-tolerant women (NP-NGT group). Multiple stepwise regression analysis was used to explore the independent factors of RBP4.Results. - Serum RBP4 levels in the P-NGT and GDM groups were significantly higher than in the NP-NOT group (34.50 +/- 9.80 mg/L and 41.64 +/- 12.21 mg/L vs 30.64 +/- 9.46 mg/L, respectively; P < 0.05) after adjusting for age, body mass index (BMI) and blood pressure. Furthermore, RBP4 levels were much higher in the GDM vs P-NGT group. Spearman's correlation analysis showed that serum RBP4 levels were positively correlated with triglycerides (TG), fasting plasma glucose, postprandial 2 h plasma glucose and HOMA-IR in pregnancy. Of these, TG and HOMA-IR (r(2) = 0.312) were independent factors of serum RBP4.Conclusion. - Serum RBP4 levels are significantly increased in pregnancy, independent of age and BMI, and are also considerably higher in pregnant women With GDM than in those with normal glucose tolerance. In addition, serum RBP4 levels appear to be a valuable marker of insulin resistance and dysfunctional lipid metabolism in pregnancy. (C) 2010 Published by Elsevier Masson SAS.