Stereoselective synthesis of axially chiral N-C bonds in N-aryl indoles.
Stereoselective synthesis of axially chiral N-C bonds in N-aryl indoles.
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DOI：
10.1021/ol0529997
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发表时间：
2006-02
期刊：
影响因子：
5.2
通讯作者：
K. Kamikawa;Shunsuke Kinoshita;H. Matsuzaka;M. Uemura
中科院分区：
文献类型：
--
作者：
K. Kamikawa;Shunsuke Kinoshita;H. Matsuzaka;M. Uemura
[反应：通过平面手性芳烃铬配合物的立体选择性芳香亲核取代反应，合成了具有轴向手性N-C键的N-芳基吲哚。通过在甲苯中回流，在位阻N-芳基吲哚铬配合物中实现了立体选择性三羰基铬迁移。
[reaction: see text] N-Aryl indoles with axially chiral N-C bonds were synthesized by stereoselective nucleophilic aromatic substitution reactions of planar chiral arene chromium complexes. Stereoselective chromium tricarbonyl migration was achieved in the sterically hindered N-aryl indole chromium complex by refluxing in toluene.