Early Bunyavirus-Host Cell Interactions.
Early Bunyavirus-Host Cell Interactions.
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DOI：
10.3390/v8050143
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发表时间：
2016-05-24
期刊：
影响因子：
--
通讯作者：
Tischler ND
中科院分区：
文献类型：
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作者：
Albornoz A;Hoffmann AB;Lozach PY;Tischler ND
布尼亚病毒科是最大的 RNA 病毒家族，在全球拥有 350 多个成员。其中一些病毒会导致牲畜和人类严重疾病。随着爆发数量和频率的不断增加，布尼亚病毒对全球公共卫生和农业生产力的威胁越来越大。然而，这些新兴病原体用于感染细胞的受体、细胞因子和内吞途径在很大程度上仍然未知。本综述的重点是布尼亚病毒感染的早期步骤，从病毒结合到内体渗透。我们介绍布尼亚病毒科各属成员在病毒受体、摄取、细胞内运输和融合方面的最新知识和进展。
The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide. Several of these viruses cause severe diseases in livestock and humans. With an increasing number and frequency of outbreaks, bunyaviruses represent a growing threat to public health and agricultural productivity globally. Yet, the receptors, cellular factors and endocytic pathways used by these emerging pathogens to infect cells remain largely uncharacterized. The focus of this review is on the early steps of bunyavirus infection, from virus binding to penetration from endosomes. We address current knowledge and advances for members from each genus in the Bunyaviridae family regarding virus receptors, uptake, intracellular trafficking and fusion.