Physically Crosslinked Biocompatible Silk-Fibroin-Based Hydrogels with High Mechanical Performance
Physically Crosslinked Biocompatible Silk-Fibroin-Based Hydrogels with High Mechanical Performance
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具有高机械性能的物理交联生物相容性丝素蛋白基水凝胶
DOI：
10.1002/adfm.201503450
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发表时间：
2016-02-09
影响因子：
19
通讯作者：
Shao, Zhengzhong
中科院分区：
文献类型：
--
作者：
Luo, Kunyuan;Yang, Yuhong;Shao, Zhengzhong
近年来，开发具有良好力学性能和生物相容性的水凝胶备受关注。本文以再生丝素（RSF）和羟丙基甲基纤维素（HPMC）为原料，通过简单的混合和加热制备了一种具有优异力学性能的新型生物相容性水凝胶。结果表明，最佳RSF/HPMC水凝胶的压缩模量和拉伸模量均大于1.0 MPa。断裂能高达3500 J m(-2)，高于软骨、软木、皮肤等天然弹性体的断裂能。凝胶机理研究表明，RSF/HPMC水凝胶具有更均匀分散的交联，以小片结构为主，这是由于HPMC和RSF分子之间的氢键和疏水相互作用的协同作用，从而使RSF/HPMC水凝胶具有优异的力学性能。这种具有生物相容性的高强度丝蛋白基水凝胶使坚固的水凝胶多样化，在生物医学领域作为承载材料的候选材料具有很大的前景。
Developing hydrogel which combines superior mechanical performance and biocompatibility attracts researchers' attention in recent years. Here, a novel biocompatible hydrogel with excellent mechanical performance, comprised of regenerated silk fibroin (RSF) and hydroxypropyl methyl cellulose (HPMC), is fabricated by simply mixing and heating. It is found that both of compressive modulus and tensile modulus of the optimal RSF/HPMC hydrogel are over 1.0 MPa. Meanwhile, the break energy is up to 3500 J m(-2), which is higher than that of some natural elastomers, such as cartilage, cork, and skin. The investigation of gelation mechanism reveals that more uniformly dispersed crosslinks dominated by smaller -sheet structures, which is attributed to the synergistic effects of hydrogen bonding and hydrophobic interaction between HPMC and RSF molecules, contribute to the superior mechanical performance of RSF/HPMC hydrogel. This biocompatible high strength silk protein based hydrogel diversifies the robust hydrogels and holds a great promise as candidates for load-bearing materials in biomedical field.