Key questions and answers about pregnancy-associated plasma protein-A.
Key questions and answers about pregnancy-associated plasma protein-A.
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DOI：
10.1016/j.tem.2012.02.008
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发表时间：
2012-05
影响因子：
10.9
通讯作者：
Conover, Cheryl A.
中科院分区：
文献类型：
--
作者：
Conover, Cheryl A.
妊娠相关血浆蛋白-A（PAPP-A）被鉴定为一种来源于胎盘但功能未知的循环蛋白质25年后，被发现是一种由多种细胞类型表达的新型锌金属蛋白酶。近年来，对PAPP-A的生物学特性及其调控机制的研究取得了很大进展，尤其是在生理和病理生理炎症损伤反应方面。但是关于这种复杂的蛋白质及其在怀孕之外的潜在临床意义还有很多东西需要了解。在这篇文章中，我们解决了一些悬而未决的问题，特别是关于它的新出现的作用，在胰岛素样生长因子（IGF）系统。
Twenty-five years after it was identified as a circulating protein derived from the placenta but of unknown function, pregnancy-associated plasma protein-A (PAPP-A) was discovered to be a novel zinc metalloproteinase expressed by a variety of cell types. Great progress has been made in understanding the biology of PAPP-A and its regulation during recent years, especially in regard to physiological and pathophysiological inflammatory injury responses. But much remains to be learned about this complex protein and its potential clinical implications outside of pregnancy. In this article we address some of the outstanding questions about PAPP-A, in particular about its newly emerging role in the insulin-like growth factor (IGF) system.
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影响因子：
4
作者：
Bale, LK;Conover, CA
通讯作者：
Conover, CA
影响因子：
4.8
作者：
Conover, Cheryl A.;Boldt, Henning B.;Powell, David R.
通讯作者：
Powell, David R.
影响因子：
5.8
作者：
Chen, BK;Leiferman, KM;Conover, CA
通讯作者：
Conover, CA
影响因子：
5.8
作者：
Byun, DW;Mohan, S;Qin, XZ
通讯作者：
Qin, XZ
DOI：
10.1111/j.1525-1438.2006.00724.x
发表时间：
2006-11-01
影响因子：
4.8
作者：
Alexiadis, M.;Mamers, P.;Fuller, P. J.
通讯作者：
Fuller, P. J.