The agricultural health study
The agricultural health study
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DOI：
10.2307/3432672
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发表时间：
1996-04-01
影响因子：
10.4
通讯作者：
Blair, A
中科院分区：
文献类型：
--
作者：
Alavanja, MCR;Sandler, DP;Blair, A
农业健康研究是一项大型前瞻性队列研究，已在北卡罗来纳州和爱荷华州启动。本研究的目的是：1）确定和量化与直接接触农药和其他农业制剂有关的男性、女性、白人和少数民族的癌症风险; 2）评估非癌症健康风险，包括神经毒性、生殖影响、免疫影响、非恶性呼吸系统疾病、肾脏疾病和儿童生长发育; 3）评估农民配偶和子女因直接接触家中、草坪和花园中使用的农药和农用化学品以及间接接触（如喷雾漂移、清洗工作服或受污染的食物或水）而可能产生的疾病风险;（4）通过定期访谈、环境和生物监测，评估当前和过去的职业和非职业农业暴露;（5）研究农业暴露、暴露生物标志物、生物效应和致癌相关遗传易感因素之间的关系;和6）识别和量化与生活方式因素（如饮食、烹饪习惯、体育活动、吸烟和饮酒以及染发剂使用）相关的癌症和其他疾病风险。在为期三年的招募期的第一年，共有26，235人参加了这项研究，其中包括19，776名注册农药施用者和6，459名注册农民施用者的配偶。据估计，当1997年汇集全部队列时，将包括大约75，000名成人研究对象。农民是最大的注册农药施用者群体，占研究目标人群的77%。这一经验与以前的前瞻性研究的入组率相比是有利的。
The Agricultural Health Study, a large prospective cohort study, has been initiated in North Carolina and Iowa. The objectives of this study are to: 1) identify and quantify cancer risks among men, women, whites, and minorities associated with direct exposure to pesticides and other agricultural agents; 2) evaluate noncancer heath risks including neurotoxicity, reproductive effects, immunologic effects, nonmalignant respiratory disease, kidney disease, and growth and development among children; 3) evaluate disease risks among spouses and children of farmers that may arise from direct contact with pesticides and agricultural chemicals used in the home, lawns and gardens, and from indirect contact, such as spray drift, laundering work clothes, or contaminated food or water; 4) assess current and past occupational and nonoccupational agricultural exposures using periodic interviews and environmental and biologic monitoring, 5) study the relationship between agricultural exposures, biomarkers of exposure, biologic effect, and genetic susceptibility factors relevant to carcinogenesis; and 6) identify and quantify cancer and other disease risks associated with lifestyle factors such as diet, cooking practices, physical activity, smoking and alcohol consumption, and hair dye use. In the first year of a 3-year enrollment period, 26,235 people have been enrolled in the study including 19,776 registered pesticide applicators and 6,459 spouses of registered farmer applicators. It is estimated that when the total cohort is assembled in 1997 it will include approximately 75,000 adult study subjects. Farmers, the largest group of registered pesticide applicators, comprise 77% of the target population enrolled in the study. This experience compares favorably with enrollment rates of previous prospective studies.