IMP-Producing Carbapenem-Resistant Klebsiella pneumoniae in the United States
IMP-Producing Carbapenem-Resistant Klebsiella pneumoniae in the United States
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DOI：
10.1128/jcm.05297-11
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发表时间：
2011-12-01
影响因子：
9.4
通讯作者：
Kallen, Alex J.
中科院分区：
文献类型：
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作者：
Limbago, Brandi M.;Rasheed, J. Kamile;Kallen, Alex J.
产生获得性碳青霉烯酶的碳青霉烯类耐药肠杆菌科（CRE）的出现和传播已造成全球公共卫生危机。在美国，产生肺炎克雷伯菌碳青霉烯酶（KPC）的CRE越来越常见，并在某些地区流行。最近在美国报告了产金属β-内酰胺酶（MBL）的CRE，这些患者在此类微生物常见的国家接受医疗护理。在这里，我们描述了三个碳青霉烯类耐药K。肺炎分离株回收儿科患者在一个单一的U。S.卫生保健机构，他们都没有国际旅行史。分离株对碳青霉烯类耐药，但对氨曲南、甲氧苄啶-磺胺甲恶唑和氟喹诺酮类敏感。脉冲场凝胶电泳结果表明，这3个菌株亲缘关系较近，且含有共同的质粒。PCR和序列分析证实，这些分离株产生IMP-4，这是一种MBL碳青霉烯酶，以前未发表在美国肠杆菌科中存在。
The emergence and spread of carbapenem-resistant Enterobacteriaceae (CRE) producing acquired carbapenemases have created a global public health crisis. In the United States, CRE producing the Klebsiella pneumoniae carbapenemase (KPC) are increasingly common and are endemic in some regions. Metallo-beta-lactamase (MBL)-producing CRE have recently been reported in the United States among patients who received medical care in countries where such organisms are common. Here, we describe three carbapenem-resistant K. pneumoniae isolates recovered from pediatric patients at a single U. S. health care facility, none of whom had a history of international travel. The isolates were resistant to carbapenems but susceptible to aztreonam, trimethoprim-sulfamethoxazole, and fluoroquinolones. The three isolates were closely related to each other by pulsed-field gel electrophoresis and contained a common plasmid. PCR and sequence analysis confirmed that these isolates produce IMP-4, an MBL carbapenemase not previously published as present among Enterobacteriaceae in the United States.