Loss of TSLC1 expression in lung adenocarcinoma: Relationships with histological subtypes, sex and prognostic significance
Loss of TSLC1 expression in lung adenocarcinoma: Relationships with histological subtypes, sex and prognostic significance
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DOI：
10.1111/j.1349-7006.2005.00075.x
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发表时间：
2005-08-01
期刊：
影响因子：
5.7
通讯作者：
Fukayama, M
中科院分区：
文献类型：
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作者：
Goto, A;Niki, T;Fukayama, M
TSLC 1（tumor suppressor in lung cancer 1）基因是最近在肺腺癌细胞系A549中通过功能互补鉴定的肿瘤抑制基因。在这项研究中，我们用化学方法检测了93例手术切除的肺腺癌中TSLC 1表达的缺失，并研究了其与临床病理参数的相关性，包括肿瘤的组织学亚型。通过单变量和多变量分析，与其他预后标志物如p53，p27和Ki-67平行分析TSLC 1表达缺失的预后意义。在非癌肺组织中，TSLC 1在支气管和细支气管上皮细胞、II型肺泡上皮细胞和支气管腺体中呈弱阳性。总的来说，93例肺腺癌中有60例TSLC 1阴性。TSLC 1主要定位于细胞质中，但也观察到细胞膜染色，尤其是在细胞-细胞粘附的位点。TSLC 1阴性肿瘤在男性（41/54例，70.0%）多于女性（19/39例，48.7%）（P
The TSLC1 (tumor suppressor in lung cancer 1) gene is a tumor suppressor recently identified through functional complementation in a lung adenocarcinoma cell line A549. In this study we immunohistochemically examined the loss of TSLC1 expression in 93 cases of surgically resected lung adenocarcinoma, and investigated its correlation with clinicopathological parameters, including histological subtypes of tumors. The prognostic significance of loss of TSLC1 expression was analyzed by univariate and multivariate analyses, in parallel with other prognostic markers such as p53, p27, and Ki-67. In non-cancerous lung tissue, TSLC1 was weakly positive in bronchial and bronchiolar epithelial cells, type II pneumocytes and bronchial glands. Overall, TSLC1 was negative in 60 of 93 lung adenocarcinomas. TSLC1 was mainly localized in the cytoplasm of the cells, but cell membrane staining was also observed, especially at sites of cell-cell adhesion. TSLC1-negative tumors were more frequently observed in male cases (41/54 cases, 70.0%) than in female cases (19/39 cases, 48.7%) (P