Uterine blood flow -: A determinant of fetal growth
Uterine blood flow -: A determinant of fetal growth
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DOI：
10.1016/s0301-2115(03)00173-8
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发表时间：
2003-09-22
期刊：
影响因子：
--
通讯作者：
Clark, KE
中科院分区：
文献类型：
--
作者：
Lang, U;Baker, RS;Clark, KE
妊娠期子宫血流的充分增加对子宫、胎盘和胎儿的生长至关重要。母体心血管适应必须提供子宫灌注，这是通过向胎盘和胎儿提供营养物质和氧气的运输来满足发育和生长的胎儿的要求所必需的。因此，子宫血流与胎儿的生长和存活密不可分。子宫血流减少可发生在急性或慢性条件下或两者的组合。妊娠高血压综合征（PIH）、妊娠期糖尿病和胎儿宫内生长受限（IUGR）患者可观察到子宫血流的慢性减少。子宫血流的慢性限制将引起胎盘和胎儿对减少的氧气和营养物供应的生长适应形式的反应。如果代偿性生长受限达到极限，则可发生胎儿宫内窘迫。在大量的子宫内生长受限的实验模型中，那些涉及子宫胎盘血供普遍减少的模型对与人类妊娠有关的问题具有重要意义。尽管存在生理差异，特别是在母体代谢和胎盘形成方面，但妊娠绵羊中的闭塞模型适用于研究有关胎儿和胎盘生长的问题。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
An adequate increase of uterine blood flow throughout gestation is essential for uterine, placental and fetal growth. Maternal cardiovascular adaptation has to provide the uterine perfusion that is necessary to meet the requirements of the developing and growing fetus by providing transport of nutrients and oxygen to the placenta and the fetus. Thus, uterine blood flow is inextricably linked to fetal growth and survival. Reductions of uterine blood flow can occur under acute or chronic conditions or in a combination of both. Chronic reductions of uterine blood flow can be observed in pregnancy-induced hyertension (PIH), diabetes mellitus in pregnancy and intrauterine growth restriction (IUGR). Chronic restrictions in uterine blood flow will elicit a placental and fetal response in the form of growth adaptation to the reduced supply of oxygen and nutrients to the conceptus. If compensatory growth restriction reaches its limits intrauterine fetal distress can ensue. Among the great number of experimental models of intrauterine growth restriction, those involving a generalized reduction in the uteroplacental blood supply are of significance to questions relating to human pregnancy. Despite physiological differences, particularly with regard to maternal metabolism and placentation, the occlusion model in the pregnant sheep is suitable for investigating questions about fetal and placental growth. (C) 2003 Elsevier Ireland Ltd. All rights reserved.