Variation in the TAS2R38 Bitterness Receptor Gene Was Associated with Food Consumption and Obesity Risk in Koreans
Variation in the TAS2R38 Bitterness Receptor Gene Was Associated with Food Consumption and Obesity Risk in Koreans
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DOI：
10.3390/nu11091973
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发表时间：
2019-09-01
期刊：
影响因子：
5.9
通讯作者：
Choi, Jeong-Hwa
中科院分区：
文献类型：
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作者：
Choi, Jeong-Hwa
苦味感受蛋白-2型味觉受体成员38(TAS2R38，T2R38)介导味觉和各种生理反应，包括与能量和肥胖相关的机制。这项研究调查了TAS2R38基因变异rs10246939C>；T是否与食物摄入量、体型以及肥胖风险有关。根据rs10246939基因，分析了韩国多农村社区队列研究的数据(1338名男性和2229名女性)，获得了六种食物类别的摄入量、酒精摄入量、吸烟状况和人体测量数据，包括身高、体重、腰围和臀围以及体重指数(BMI)。研究结果表明，携带TT基因的女性比其他基因携带者消耗更多的水果(调整后p=0.025)，体重(调整后p=0.046)和体重指数(调整后p=0.003)显著高于其他基因携带者。携带TT基因的女性患肥胖症的风险也增加了1.75倍(95%可信区间：1.31-2.36)。遗传变异对男性膳食摄入量的影响很小，但有增加肥胖风险的趋势。综上所述，TAS2R38 rs10246939变异与韩国人的饮食摄入有关，并增加了他们肥胖的风险。尽管需要在更大的队列中进行更详细的统计分析，但目前的研究表明，作为一种遗传预测标记，TAS2R38苦味受体变异可能在肥胖预防和治疗中具有重要意义。
Bitterness-sensing protein taste receptor type-2 member 38 (TAS2R38, T2R38) mediates taste perception and various physiological responses, including energy- and adiposity-related mechanisms. This study examined whether the genetic variant rs10246939 C > T in TAS2R38 was associated with food intake and body size as well as obesity risk. Data from the Korean Multi-Rural Communities Cohort study (1338 males and 2229 females) were analyzed to obtain the intake of six food groups, alcohol consumption, smoking status and anthropometric measurements, including height, weight, waist and hip circumference, and body mass index (BMI), according to the rs10246939 genotype. Findings suggested that females with the TT genotype consumed more fruit (adjusted p = 0.025) and had significantly higher body weights (adjusted p = 0.046) and BMIs (adjusted p = 0.003) than individuals with other genotypes. Having the TT genotype also increased the risk of obesity by 1.75-fold (95% confidence interval: 1.31-2.36) in females. The genetic variation had a minimal influence on the males' dietary intake, but tended to increase the adiposity risk. In conclusion, TAS2R38 rs10246939 variation was associated with Koreans' dietary intake and increased their risk of obesity. Although more detailed statistical analyses in the larger cohort are required, current study suggested that, as a genetic predictive marker, TAS2R38 bitterness receptor variations may have a large implication in obesity prevention and treatment.