On the classification of pathways in the auditory midbrain, thalamus, and cortex.

On the classification of pathways in the auditory midbrain, thalamus, and cortex.
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DOI:
10.1016/j.heares.2010.12.012
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发表时间:
2011-06
期刊:
影响因子:
2.8
通讯作者:
Sherman, Murray
Sherman, Murray
中科院分区:
医学1区
文献类型:
--
作者:
Lee, Charles C.;Sherman, Murray

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听觉前脑通路表现出多种形态和生理特性,这些特性是其在听觉处理中特定神经生物学作用的基础。从解剖学上讲,这种投射可以通过它们的末端大小、树枝化模式和突触后树突位置来区分。这些结构特征与多种突触后生理特性相关,例如 EPSP 振幅、短期可塑性和突触后受体类型。总而言之,这些突触特性分为两个主要类别,主要与信息承载(第 1 类)或调节(第 2 类)角色相关,并已被用来描述信息流经听觉中脑、丘脑和皮层的主要路线。此外,这些突触特性引发了有关听觉信息神经元处理的尚未探索的问题,例如听觉前脑输入的收敛整合和长期可塑性。
Auditory forebrain pathways exhibit several morphological and physiological properties that underlie their specific neurobiological roles in auditory processing. Anatomically, such projections can be distinguished by their terminal size, arborization patterns, and postsynaptic dendritic locations. These structural features correlate with several postsynaptic physiological properties, such as EPSP amplitude, short-term plasticity, and postsynaptic receptor types. Altogether, these synaptic properties segregate into two main classes that are associated with either primarily information-bearing (Class 1) or modulatory (Class 2) roles, and have been used to delineate the principle routes of information flow through the auditory midbrain, thalamus, and cortex. Moreover, these synaptic properties engender as yet unexplored issues regarding the neuronal processing of auditory information, such as the convergent integration and long-term plasticity of auditory forebrain inputs.
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