Maternal Preeclampsia and Risk for Cardiovascular Disease in Offspring
Maternal Preeclampsia and Risk for Cardiovascular Disease in Offspring
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DOI：
10.1007/s11906-014-0475-3
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发表时间：
2014-09-01
影响因子：
5.6
通讯作者：
Contag, Stephen
中科院分区：
文献类型：
--
作者：
Herrera-Garcia, Guadalupe;Contag, Stephen
妊娠期高血压疾病（HDP）与终生心血管风险增加相关，包括中风、心肌疾病、冠状动脉疾病和外周动脉疾病。这两个实体有共同的风险因素，如肥胖，胰岛素抵抗，糖尿病和高血压。本文将评估目前的文献对母亲和胎儿心血管风险造成的HDP。Barker等人的里程碑式研究表明，生长受限婴儿的心血管风险增加，这也可能与HDP相关。研究表明，HDP可能对后代的血管和肾单位发育产生影响，特别是在内皮和炎症标志物方面。为了控制混杂变量并更好地了解HDP与终生心血管风险之间的关系，未来的研究将需要遵循产妇及其后代的血压和代谢特征。
Hypertensive disease of pregnancy (HDP) has been associated with elevated lifetime cardiovascular risk, including stroke, myocardial disease, coronary artery disease, and peripheral arterial disease. These two entities share common risk factors such as obesity, insulin resistance, diabetes, and hypertension. This article will evaluate the current literature on the maternal and fetal cardiovascular risks posed by HDP. The landmark study by Barker et al. demonstrated increased cardiovascular risk in growth-restricted infants, which may also be associated with HDP. Research has demonstrated the effects that HDP may have on the vascular and nephron development in offspring, particularly with respect to endothelial and inflammatory markers. In order to control for confounding variables and better understand the relationship between HDP and lifetime cardiovascular risk, future research will require following blood pressure and metabolic profiles of the parturients and their offspring.