Nasopharyngeal carriage of Streptococcus pneumoniae by adults and children in community and family settings
Nasopharyngeal carriage of Streptococcus pneumoniae by adults and children in community and family settings
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DOI：
10.1086/381547
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发表时间：
2004-03-01
影响因子：
11.8
通讯作者：
Rubinstein, E
中科院分区：
文献类型：
--
作者：
Regev-Yochay, G;Raz, M;Rubinstein, E
比较同一人群中成人与儿童（年龄小于或等于6岁）的肺炎链球菌携带率。分析了1300名成人和404名儿童的鼻咽培养结果。S.只有4%的成年人携带肺炎，而同一社区的儿童则为53%。年龄小，日托中心出勤率，有年幼的兄弟姐妹，以及在筛查前一个月内没有使用抗生素与儿童的高携带率相关，而与成人携带相关的唯一风险因素是筛查当天存在呼吸道感染。S.肺炎血清型分布和抗生素耐药模式在成人和儿童之间存在差异。同一血清型的分离株--甚至同一克隆的分离株--在儿童和成人之间的抗生素敏感性模式不同。在对151对儿童及其父母和32对兄弟姐妹的亚组分析中，发现了S。不能证明肺炎。
The rate of Streptococcus pneumoniae carriage among adults was compared with that among children (age, less than or equal to6 years) in the same population. Nasopharyngeal culture results for 1300 adults and 404 children were analyzed. S. pneumoniae was carried by only 4% of the adults, compared with 53% of children in the same community. Young age, day care center attendance, having young siblings, and no antibiotic use during the month before screening were associated with the high carriage rate among children, whereas the only risk factor associated with carriage among adults was the presence of a respiratory infection on the screening day. S. pneumoniae serotype distribution and antibiotic resistance patterns differed between adults and children. Isolates of the same serotype - even of the same clone - differed in their antibiotic susceptibility patterns between children and adults. In a subanalysis of 151 pairs of children and their parents and of 32 pairs of siblings, intrafamilial transmission of S. pneumoniae could not be demonstrated.