Transmission of epidemic Vibrio cholerae O1 in rural western Kenya associated with drinking water from Lake Victoria:: An environmental reservoir for cholera?
Transmission of epidemic Vibrio cholerae O1 in rural western Kenya associated with drinking water from Lake Victoria:: An environmental reservoir for cholera?
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DOI：
10.4269/ajtmh.1999.60.271
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发表时间：
1999-02-01
影响因子：
3.3
通讯作者：
Slutsker, L
中科院分区：
文献类型：
--
作者：
Shapiro, RL;Otieno, MR;Slutsker, L
撒哈拉以南非洲的霍乱发病率和死亡率是世界上最高的。1997年，肯尼亚西部发生霍乱疫情。在1997年6月至1998年3月期间，肯尼亚西部尼扬扎省的医院报告了14 275例霍乱病人。有547人死亡（病死率= 4%）。在31株O1型霍乱弧菌中，除1株外，其余均对四环素敏感。我们对61例霍乱患者和年龄、性别和临床匹配的对照进行了病例对照研究。多变量分析表明，霍乱的危险因素是饮用维多利亚湖或小溪的水，与水泻患者分享食物，以及参加葬礼宴会。与其他霍乱病原体相比，霍乱在维多利亚湖沿岸村庄的居民中更为常见。霍乱已成为肯尼亚西部一个重要的公共卫生问题，并可能成为该地区的地方病病原体。
Sub-Saharan Africa has the highest reported cholera incidence and mortality rates in the world. In 1997, a cholera epidemic occurred in western Kenya. Between June 1997 and March 1998, 14,275 cholera admissions to hospitals in Nyanza Province in western Kenya were reported. There were 547 deaths (case fatality rate = 4%). Of 31 Vibrio cholerae O1 isolates tested, all but one were sensitive to tetracycline. We performed a case-control study among 61 cholera patients and age-, sex-, and clinic-matched controls. Multivariate analysis showed that risk factors for cholera were drinking water from Lake Victoria or from a stream, sharing food with a person with watery diarrhea, and attending funeral feasts. Compared with other diarrheal pathogens, cholera was more common among persons living in a village bordering Lake Victoria. Cholera has become an important public health concern in western Kenya, and may become an endemic pathogen in the region.