The impact of Long COVID on Health-Related Quality-of-Life using OpenPROMPT
The impact of Long COVID on Health-Related Quality-of-Life using OpenPROMPT
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使用 OpenPROMPT 评估长期新冠肺炎对健康相关生活质量的影响
DOI：
10.1101/2023.12.06.23299601
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Carlile O
中科院分区：
文献类型：
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作者：
Carlile O
背景长 新冠肺炎是影响患者健康、卫生服务和劳动力的主要问题。为了优化未来针对 COVID-19 的干预措施的设计，并更好地规划和分配卫生资源，量化这种新型疾病的健康和经济负担至关重要。方法经英国 NHS 批准，我们开发了 OpenPROMPT，这是一项英国队列研究，衡量长期 COVID 对健康相关生活质量 (HRQoL) 的影响。 OpenPROMPT 邀请使用智能手机应用程序对患者报告结果测量 (PROM) 进行回复，并在 2022 年 11 月至 2023 年 10 月之间招募。我们使用经过验证的 EuroQol EQ-5D 调查问卷和英国价值集，使用线性混合模型为患有和不患有长期新冠肺炎的受访者制定负效用分数（1-效用），并计算了长期新冠肺炎的后续质量调整生命月数 (QALM)。结果我们使用了来自6,070 名参与者中，24.7% 的人自我报告长期感染新冠病毒。在多变量回归中，长期感染新冠病毒对 HRQoL 具有一致的影响，与未报告长期感染新冠病毒的人相比，报告生活质量下降的可能性很高（OR：22，95% CI：12.35-39.29）。在所有调查回复中，报告残疾是 HRQoL 损失的最大预测因素（OR：60.2，95% CI：27.79-130.57）。自我报告的长期新冠肺炎与 0.37 QALM 损失相关。结论我们发现长期新冠肺炎对生活质量产生了重大影响，给患者和卫生服务带来了重大负担。我们强调需要对长期新冠肺炎持续提供支持和研究，因为 HRQoL 评分与患有多发性硬化症、心力衰竭和肾脏疾病等疾病的患者相比不利。
BackgroundLong COVID is a major problem affecting patient health, the health service, and the workforce. To optimise the design of future interventions against COVID-19, and to better plan and allocate health resources, it is critical to quantify the health and economic burden of this novel condition.MethodsWith the approval of NHS England, we developed OpenPROMPT, a UK cohort study measuring the impact of long COVID on health-related quality-of-life (HRQoL). OpenPROMPT invited responses to Patient Reported Outcome Measures (PROMs) using a smartphone application and recruited between November 2022 and October 2023. We used the validated EuroQol EQ-5D questionnaire with the UK Value Set to develop disutility scores (1-utility) for respondents with and without Long COVID using linear mixed models, and we calculated subsequent Quality-Adjusted Life-Months (QALMs) for long COVID.ResultsWe used data from 6,070 participants where 24.7% self-reported long COVID. In multivariable regressions, long COVID had a consistent impact on HRQoL, showing a high probability of reporting loss in quality-of-life (OR: 22, 95% CI:12.35-39.29) compared with people who did not report long COVID. Reporting a disability was the largest predictor of losses of HRQoL (OR: 60.2, 95% CI: 27.79-130.57) across survey responses. Self-reported long COVID was associated with an 0.37 QALM loss.ConclusionsWe found substantial impacts on quality-of-life due to long COVID, representing a major burden on patients and the health service. We highlight the need for continued support and research for long COVID, as HRQoL scores compared unfavourably to patients with conditions such as multiple sclerosis, heart failure, and renal disease.