Morphological assessment of reparative regeneration of experimental bleeding liver wounds in the treatment of hemostatic agent Surgitamp and granular sorbent Molselect G-50
Morphological assessment of reparative regeneration of experimental bleeding liver wounds in the treatment of hemostatic agent Surgitamp and granular sorbent Molselect G-50
复制标题
止血剂 Surgitamp 和颗粒吸附剂 Molselect G-50 治疗实验性出血肝脏创面修复再生的形态学评估
DOI：
10.19163/1994-9480-2023-20-1-73-80
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
V. Troshin
中科院分区：
文献类型：
--
作者：
Y. Parkhisenko;A. K. Vorontsov;E. Cherednikov;S. Barannikov;A. Korsakov;V. Troshin
腹部外伤腹腔内出血的处理是急诊外科中最严重的问题之一。这些疾病最常见的原因是肝损伤。对于手术止血，局部止血剂和颗粒吸附剂变得越来越普遍。本研究的目的是在体内研究止血剂Surgitamp和吸附剂Molselect G-50治疗过程中模拟出血肝伤口的止血特性和修复性再生的形态学特征。实验在30只实验动物灰鼠兔上进行。在复制出血肝伤口模型后，通过将Molselect G-50（4.0 g）粉末吸附剂应用于伤口，然后用Surgitamp止血纱布（4.0 x 2.0 cm）填塞，在实验组（n = 15）中止血。通过使用PGA-3.0缝线的U形缝线进行对照肝脏伤口止血，直至伤口边缘收敛。在实验的第7、14和28天进行形态学研究。实验研究表明，实验组止血时间为280.0（264.0308.0）sec，对照组止血时间为461.0（420.0501.0）sec。形态学研究使我们能够建立与对照组相比，实验模拟肝创伤修复性再生的速度和质量的差异。使用Molselect G-50与Surgistamp联合用于兔肝出血伤口局部止血的实验研究使我们得出结论，这种组合不仅可以可靠地止血，而且还可以促进修复再生的刺激。
The problem of treating intra-abdominal bleeding in abdominal trauma is one of the most serious in urgent surgery. The most common cause of these hemorrhages is liver damage. For surgical hemostasis, local hemostatics and granular sorbents are becoming increasingly common. The aim of the study was to study in vivo the hemostatic properties and morphological features of the reparative regeneration of simulated bleeding liver wounds during treatment with the hemostatic agent Surgitamp and the sorbent Molselect G-50. The experiments were performed on 30 laboratory animals Chinchilla rabbits. After reproducing the model of a bleeding liver wound, bleeding was stopped in the experimental group (n = 15) by applying Molselect G-50 (4.0 g) powdered sorbent into the wound, followed by tamponing with Surgitamp hemostatic gauze (4.0 x 2.0 cm). Hemostasis in the control liver wound was carried out by applying a U-shaped suture with a PGA-3.0 thread until the edges of the wound converged. Morphological studies were performed on the 7th, 14th and 28th days of the experiment. Experimental studies have shown that the time to stop bleeding in the experimental group was 280.0 (264.0308.0) sec, in the control, the time of hemostasis was later 461.0 (420.0501.0) sec. Morphological studies have allowed us to establish differences in both the rate and quality of reparative regeneration of experimental simulated liver wounds compared with the control. Experimental studies using Molselect G-50 in combination with Surgistamp for local hemostasis of bleeding liver wounds in rabbits allowed us to conclude that such a combination makes it possible not only to reliably stop bleeding, but also promotes the stimulation of reparative regeneration.