Antimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp.
Antimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp.
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DOI：
10.1080/14756366.2016.1180596
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发表时间：
2016-12-01
影响因子：
5.6
通讯作者：
Angiolella, Letizia
中科院分区：
文献类型：
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作者：
Carradori, Simone;Chimenti, Paola;Angiolella, Letizia
有限的合成抗真菌药物库和耐药念珠菌菌株的出现促使研究人员对天然存在的化合物或其半合成衍生物进行研究，以提出具有降低毒性的新的创新打击化合物或新的抗真菌组合。首次对藏红花柱头中两种生物活性化合物藏红花素1和番红花醛及其半合成衍生物的抗念珠菌作用进行了研究，从最小抑菌浓度/最小杀真菌浓度（MIC/MFC）值、增效作用和减少胚管形成等方面获得了良好的生物学结果。Safranal及其硫代氨基脲衍生物5对念珠菌具有良好的抑菌活性。
The limited arsenal of synthetic antifungal agents and the emergence of resistant Candida strains have prompted the researchers towards the investigation of naturally occurring compounds or their semisynthetic derivatives in order to propose new innovative hit compounds or new antifungal combinations endowed with reduced toxicity. We explored the anti-Candida effects, for the first time, of two bioactive compounds from Crocus sativus stigmas, namely crocin 1 and safranal, and some semisynthetic derivatives of safranal obtaining promising biological results in terms of minimum inhibitory concentration/minimum fungicidal concentration (MIC/MFC) values, synergism and reduction in the germ tube formation. Safranal and its thiosemicarbazone derivative 5 were shown to display good activity against Candida spp.