PERIAXIN, A NOVEL PROTEIN OF MYELINATING SCHWANN-CELLS WITH A POSSIBLE ROLE IN AXONAL ENSHEATHMENT
PERIAXIN, A NOVEL PROTEIN OF MYELINATING SCHWANN-CELLS WITH A POSSIBLE ROLE IN AXONAL ENSHEATHMENT
复制标题
DOI：
10.1016/0896-6273(94)90208-9
复制
发表时间：
1994-03-01
期刊：
影响因子：
16.2
通讯作者：
BROPHY, PJ
中科院分区：
文献类型：
--
作者：
GILLESPIE, CS;SHERMAN, DL;BROPHY, PJ
我们报告的克隆和亚细胞定位的一种新的雪旺细胞特异性蛋白质的147 kD，我们命名为periaxin。周蛋白在一级序列中具有显著的重复五聚体单元结构域。它在包裹轴突的膜的第一个未压实的螺旋中表达，并且在大鼠坐骨神经中蛋白质的进一步合成与髓鞘的沉积平行。在成熟的髓鞘中，轴周蛋白与髓鞘相关糖蛋白共定位在充满细胞质的鞘的轴周区域中，但被排除在致密的髓鞘之外。我们建议，轴周蛋白在轴突-神经胶质细胞的相互作用中发挥作用，可能是通过与雪旺细胞质膜的轴周区域中的髓磷脂相关糖蛋白等膜蛋白的胞质结构域相互作用。
We report the cloning and subcellular localization of a novel Schwann cell-specific protein of 147 kd that we have named periaxin. Periaxin has a remarkable domain of repetitive pentameric units in the primary sequence. It is expressed in the first uncompacted whorls of membrane that ensheathe the axon, and further synthesis of the protein in the rat sciatic nerve parallels the deposition of myelin. In mature myelin, periaxin colocalizes with the myelin-associated glycoprotein in the cytoplasm-filled periaxonal regions of the sheath but is excluded from compact myelin. We propose that periaxin has a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane.