Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo
Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo
复制标题
聚集诱导发射发光剂用于体内恶性肿瘤的特异性识别
DOI：
10.1007/s11426-019-9677-7
复制
发表时间：
2020-02-19
影响因子：
9.6
通讯作者：
Bao, Shisan
中科院分区：
文献类型：
--
作者：
Shen, Jianlei;Tao, Kun;Bao, Shisan
结直肠癌（Colorectal cancer， CRC）仍然是癌症的主要杀手，这主要是由于缺乏具有敏感性/特异性的早期检测生物标志物。传统的组织病理学是实践中的金标准方法，但仍存在一些问题（误诊和等待时间长）。聚集诱导发射（AIE）是一种新型的光物理现象，已广泛应用于包括恶性细胞在内的生物体内成像，在高浓度状态下具有显著的成像对比度和增强的发射。然而，AIE染料是否能在体内特异性地识别恶性细胞尚不清楚。对恶性细胞进行特异性标记的巨大挑战可能归因于肿瘤组织中复杂的成分。本研究采用一种基于AIE染料的线粒体靶向组织学染色策略来定位新结直肠癌的肿瘤和转移轨迹。这种新颖的方法具有巨大的潜力，革命性的临床诊断和干预破坏性恶性肿瘤。
Colorectal cancer (CRC) is still a major killer, mainly due to the lack of early detection biomarker with sensitivity/specificity. Conventional histopathology is the gold standard approach in practice, but there are still some issues (false diagnosis and long waiting period). Aggregation-induced emission (AIE) is a novel photophysical phenomenon which has been widely utilized for biological imaging in vivo, including malignant cells, showing remarkable imaging contrast and enhanced emission in high concentrated state. However, it is unclear if AIE dyes can identify malignant cells specifically in vivo. A great challenge for specific labeling of malignant cells is probably ascribed to the complex compositions in tumor tissues. Herein, an AIE dye-based mitochondria-targeted histological staining strategy was employed to localize cancer and the metastatic track in the fresh colorectal cancer. This novel approach holds great potential to revolutionize the clinical diagnosis and intervention for devastating malignancy.