The effect of anaesthetics on blood perfusion in transplanted mouse tumours.
The effect of anaesthetics on blood perfusion in transplanted mouse tumours.
复制标题
麻醉剂对移植小鼠肿瘤血液灌注的影响。
作者：
G. Zanelli;P. B. Lucas;J. Fowler;Song;Levitt;Wong
本文用~（86）Rb、~（125）I-人血清白蛋白和~（51）Cr标记红细胞，观察了麻醉药戊巴比妥钠（Nembutal）和乌拉坦（urethane）对5种小鼠移植性肿瘤和正常器官血液灌注、血容量和白蛋白渗漏的影响。发现戊巴比妥使肿瘤的相对血液灌注增加1-3至2-0倍，使肾脏的相对血液灌注增加1-7至3-0倍，但肌肉灌注下降至对照组的0-3-0-5倍。发现氨基甲酸乙酯的影响具有剂量依赖性，通常与戊巴比妥的方向相同，但较小。两种麻醉剂都使肿瘤（C3 H乳腺癌除外）和肾脏的血容量减少了0-2至0-8倍。麻醉的持续时间对肿瘤或正常器官的相对血液灌注和血容量的平台值没有影响，但Nembutal略微延迟了86 Rb的摄取，并降低了白蛋白渗漏的速率。
Rubidium-86, 125I-human serum albumin and 51Cr-labelled red cells have been used to investigate the effects of the anaesthetics Nembutal (pentobarbitone sodium) and urethane on blood perfusion, blood volume and albumin leakage in 5 types of transplanted mouse tumour and in normal organs. Nembutal was found to increase the relative blood perfusion by a factor of 1-3 to 2-0 in tumours and by a factor of 1-7 to 3-0 in kidneys but muscle perfusion fell to 0-3-0-5 that of controls. The effects of urethane were found to be dose dependent, generally in the same direction as for Nembutal, and smaller. Both anaesthetics reduced the blood volume of tumours (except for the C3H mammary carcinoma) and of kidneys by factors of 0-2 to 0-8. The duration of anaesthesia had no effect on the plateau values of relative blood perfusion and blood volume in either tumours or normal organs, but Nembutal delayed slightly the 86Rb uptake and decreased the rate of albumin leakage.