Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?
Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?
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DOI：
10.1097/aln.0000000000002047
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发表时间：
2018-04
期刊：
影响因子：
8.8
通讯作者：
Jevtovic-Todorovic V
中科院分区：
文献类型：
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作者：
Jevtovic-Todorovic V
在过去的 15 年里，我们目睹了大量的研究报告，这些报告令人不安地担心，在神经元网络形成的关键阶段，非常年轻的哺乳动物大脑可能容易受到体内平衡的干扰。尽管对最初的动物报告进行了审查，但最近的报告表明，临床使用的全身麻醉剂和镇静剂确实有可能对大脑发育造成严重破坏。这可能是由于正常神经元和神经胶质活动的扰动造成的，只有发生这种扰动才能使个体失去意识并对疼痛不敏感。由于不受干扰的神经元和神经胶质细胞的活动和通讯对于神经元回路的形成至关重要 1, 2，因此这些药物被认为不利于正常的神经元和神经胶质细胞的发育，导致认知和社会情感行为发展的改变。
Over the past 15 years we have been witness to numerous research reports bringing an uncomfortable concern that very young mammalian brain could be susceptible to disturbances in homeostasis during critical stages of neuronal networks formation. Despite scrutiny of initial animal reports, more recent reports suggest that there is a real possibility that clinically-used general anesthetics and sedatives could cause powerful disruptions of brain development. This is likely due to perturbations of normal neuronal and glial activity, which has to occur in order for an individual to be rendered unconscious and insensitive to pain. Since undisturbed neuronal and glial activity and communication are crucially important for neuronal circuits formation1, 2, these pharmacological agents have been thought to be detrimental to normal neuronal and glial development, resulting in alterations in cognitive and socio-emotional behavioral development.