Fast single photon avalanche photodiode-based time-resolved diffuse optical tomography scanner.
Fast single photon avalanche photodiode-based time-resolved diffuse optical tomography scanner.
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DOI：
10.1364/boe.6.003596
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发表时间：
2015-09
影响因子：
3.4
通讯作者：
Ying Mu;M. Niedre
中科院分区：
文献类型：
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作者：
Ying Mu;M. Niedre
漫射光学断层扫描 (DOT) 的分辨率是一个长期存在的问题，主要受到生物组织中光散射程度高的限制。我们之前表明，时间分辨 DOT 中激光脉冲后的早期时间点源和探测器对之间光子散射的减少高度依赖于仪器的时间响应。为此，我们开发了一种基于单光子雪崩光电二极管（SPAD）的新型时间分辨点扫描仪。该仪器使用一系列快速 SPAD、飞秒钛蓝宝石激光器和单光子计数电子器件。组合起来，整个仪器时间脉冲响应函数宽度为 59 ps。在本文中，我们报告了该仪器的设计，并验证了其在大约小动物大小的对称和不规则形状的光学模型中的操作。我们能够准确地重建多达 4 个吸收内含物的大小和位置，并提高早期时间窗口的图像质量。我们将这些结果主要归因于我们仪器的快速响应时间。这些数据说明了快速 SPAD 探测器在时间分辨 DOT 中的潜在用途。
Resolution in diffuse optical tomography (DOT) is a persistent problem and is primarily limited by high degree of light scatter in biological tissue. We showed previously that the reduction in photon scatter between a source and detector pair at early time points following a laser pulse in time-resolved DOT is highly dependent on the temporal response of the instrument. To this end, we developed a new single-photon avalanche photodiode (SPAD) based time-resolved DOT scanner. This instrument uses an array of fast SPADs, a femto-second Titanium Sapphire laser and single photon counting electronics. In combination, the overall instrument temporal impulse response function width was 59 ps. In this paper, we report the design of this instrument and validate its operation in symmetrical and irregularly shaped optical phantoms of approximately small animal size. We were able to accurately reconstruct the size and position of up to 4 absorbing inclusions, with increasing image quality at earlier time windows. We attribute these results primarily to the rapid response time of our instrument. These data illustrate the potential utility of fast SPAD detectors in time-resolved DOT.