The discovery of BMAA, and examples of biomagnification and protein incorporation involving other non-protein amino acids
The discovery of BMAA, and examples of biomagnification and protein incorporation involving other non-protein amino acids
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DOI：
10.3109/17482960903268700
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Bell, E. Arthur
中科院分区：
文献类型：
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作者：
Bell, E. Arthur
由于 ALS/PDC 症状与麻痹性疾病山黧豆症的症状相似，因此对来自关岛的苏铁种子进行了分析，以确定是否存在非蛋白质氨基酸 b-ODAP，已知这种氨基酸会导致山黧豆症。虽然没有检测到 b-ODAP，但分离出了一种新的非蛋白质氨基酸，现在称为 BMAA。灵长类动物比啮齿动物对 BMAA 更敏感。长期摄入低浓度的 BMAA 可能会导致 ALS/PDC。已知一些非蛋白质氨基酸，包括软骨藻酸和吲哚啉，具有生物放大作用。其他非蛋白质氨基酸，包括氮杂环丁烷-2-羧酸、刀豆氨酸以及含硒的胱氨酸和蛋氨酸类似物已被证明被错误掺入蛋白质中。也许 BMAA 不会是死于神经系统疾病的人脑组织中发现的唯一非蛋白质氨基酸。
Because of the similarity of ALS/PDC symptoms to those of the paralytic disease lathyrism, cycad seeds from Guam were analyzed for the presence of the non-protein amino acid b-ODAP, which is known to cause lathyrism. Although b-ODAP was not detected, a novel non-protein amino acid, now known as BMAA, was isolated. Primates are more sensitive to BMAA than rodents. It is possible that BMAA when ingested at a low concentration over a long period might be responsible for ALS/PDC. Some non-protein amino acids, including domoic acid and indospicine, are known to be biomagnified. Other non-protein amino acids including azetidine-2-carboxylic acid, canavanine, and selenium containing analogues of cystine and methionine have been shown to be misincorporated into proteins. Perhaps BMAA will not be the only nonprotein amino acid that will be found in the brain tissues of those who died of a neurological disease.